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Refractive Correction

Spectacles for Lazy Eye (SPECTRA Trial)

N/A
Recruiting
Led By Benjamin Thompson, PhD
Research Sponsored by Centre for Eye and Vision Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Anisometropic amblyopia (difference of ≥0.50D spherical equivalent or ≥1.50D astigmatism between eyes) or mixed mechanism amblyopia (strabismus and anisometropia)
18-39 (inclusive) years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approx. 15-20 mins, on completion of study (week 24)
Awards & highlights

Summary

This trial aims to see if correcting vision in adults with amblyopia can improve their visual acuity and other visual functions. The study will use measures related to vision, binocular vision, and eye

Who is the study for?
This trial is for adults aged 18-39 with 'lazy eye' who have a specific difference in vision strength or astigmatism between their eyes. They must be generally healthy and have not received the optimal glasses prescription yet.
What is being tested?
The study tests if wearing the right spectacles can improve vision in adults with amblyopia (lazy eye). It will measure changes in visual acuity, binocular vision, and eye movements to assess improvement.
What are the potential side effects?
Since this trial involves non-invasive optical correction using spectacles, there are no direct side effects associated with typical medical interventions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have a significant vision difference between my eyes or both misalignment and vision difference.
Select...
I am between 18 and 39 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approx. 15-20 mins, on completion of study (week 24)
This trial's timeline: 3 weeks for screening, Varies for treatment, and approx. 15-20 mins, on completion of study (week 24) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Best corrected visual acuity of the amblyopic eye post-intervention
Eye
Secondary outcome measures
Amblyopic eye contrast sensitivity during intervention
Amblyopic eye contrast sensitivity post-intervention
Amblyopic eye contrast sensitivity pre-intervention
+33 more
Other outcome measures
Interventional procedure
Electrical potentials post-intervention
Electrical potentials pre-intervention

Trial Design

1Treatment groups
Experimental Treatment
Group I: Optical correctionExperimental Treatment1 Intervention
Prescription of spectacles for full-time wear to correct refractive error
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Spectacles
2010
N/A
~3350

Find a Location

Who is running the clinical trial?

The Hong Kong Polytechnic UniversityOTHER
516 Previous Clinical Trials
72,018 Total Patients Enrolled
University of WaterlooOTHER
126 Previous Clinical Trials
214,764 Total Patients Enrolled
Centre for Eye and Vision ResearchLead Sponsor
2 Previous Clinical Trials
130 Total Patients Enrolled
~18 spots leftby Nov 2026
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