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Effort-based Decision-Making Task for Depression (BBQS Trial)

N/A
Waitlist Available
Led By Christopher J Rozell, Ph.D.
Research Sponsored by Georgia Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Matched control group: Current diagnosed psychiatric disorder (e.g., anxiety, depression, bipolar disorder), current pregnancy, BMI > 35, currently on antipsychotics
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights
No Placebo-Only Group

Summary

"This trial aims to create a new test called HORMES to measure reduced motivation in patients with major depressive disorder. The test will assess how patients respond during daily activities and measure their physiological responses. The

Who is the study for?
This trial is for individuals with major depressive disorder (MDD), particularly those who experience anhedonia or a lack of pleasure in daily activities. Participants should have difficulty making efforts, which affects their day-to-day functioning.
What is being tested?
The study is testing a new behavioral test called HORMES designed to objectively assess motivation and effort during everyday tasks. It will measure brain activity, autonomic system function, and energy use while participants complete a decision-making task that requires physical effort.
What are the potential side effects?
Since the intervention involves only a decision-making task without medical treatments or drugs, there are no direct side effects associated with medications. However, participation may involve psychological discomfort due to confronting challenging tasks.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I do not have a psychiatric disorder, am not pregnant, my BMI is 35 or less, and I am not taking antipsychotics.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Time spent in high-effort "rooms"

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Effort-based decision-makingExperimental Treatment1 Intervention
Participants perform a virtual-reality-based task in which they expend effort to receive virtual rewards.

Find a Location

Who is running the clinical trial?

Emory UniversityOTHER
1,705 Previous Clinical Trials
2,607,294 Total Patients Enrolled
62 Trials studying Depression
9,495 Patients Enrolled for Depression
Georgia Institute of TechnologyLead Sponsor
51 Previous Clinical Trials
5,540 Total Patients Enrolled
1 Trials studying Depression
10 Patients Enrolled for Depression
Icahn School of Medicine at Mount SinaiOTHER
909 Previous Clinical Trials
542,053 Total Patients Enrolled
38 Trials studying Depression
5,972 Patients Enrolled for Depression
~60 spots leftby Aug 2029
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