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Home-Based Cognitive Training for Multiple Sclerosis (HOBSCOTCH-MS Trial)

N/A

Recruiting

Led By Heather A Wishart, PhD

Research Sponsored by Dartmouth-Hitchcock Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Literate, English-speaking with grade 12 or equivalent in education

Self-reported diagnosis of MS

Must not have

Cognitive dysfunction that precludes participation in giving informed consent

History of progressive neurodegenerative disease (dementia)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline (pre-hobscotch-ms) and post-hobscotch-ms, approximately 9 weeks later.

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether a program called HOBSCOTCH, which helps people with epilepsy manage their condition at home, can be adapted and used by people with multiple sclerosis (MS). The trial

Who is the study for?

This trial is for people aged 20-65 with MS who feel they have memory or cognitive issues. They must be able to read and speak English, have completed at least a grade 12 level of education, and have access to a telephone and the internet.

What is being tested?

The HOBSCOTCH program for epilepsy self-management is being tested to see if it can help improve the quality of life for those with MS. Participants will attend nine virtual sessions with a coach and complete questionnaires about their condition before and after these sessions.

What are the potential side effects?

Since this intervention involves educational training rather than medication, traditional side effects are not expected. However, participants may experience fatigue or stress from attending regular sessions or completing surveys.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have completed at least 12 years of education and can speak and read English.

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I have been diagnosed with multiple sclerosis.

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I am between 20 and 65 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am able to understand and give consent for my treatment.

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I have a progressive brain disorder that affects memory and thinking.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline (pre-hobscotch-ms) and post-hobscotch-ms, approximately 9 weeks later.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline (pre-hobscotch-ms) and post-hobscotch-ms, approximately 9 weeks later.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (pre-hobscotch-ms) and post-hobscotch-ms, approximately 9 weeks later. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in quality of life as measured by comparing FAMS-Functional Assessment of Multiple Sclerosis v4.0 scores pre- and post-HOBSCOTCH-MS intervention.

Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSCOTCH-MS intervention.

Secondary study objectives

Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-MS intervention.

Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-MS intervention.

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: MS Participant with Cognitive DysfunctionExperimental Treatment1 Intervention

Participants will receive the HOBSCOTCH-MS intervention consisting of 1:1 sessions delivered once per week including: * 1 pre-HOBSCOTCH Session (on webcam or by phone) * 1 educational session (on webcam) * 6 HOBSCOTCH intervention sessions (webcam or phone) * 1 wrap-up session (webcam or phone)

0 / 5Eligibility criteria met