Advanced Imaging for Post-Traumatic Osteoarthritis

Recruiting in Palo Alto (17 mi)

Overseen by J L Marsh, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: J L Marsh

No Placebo Group

Trial Summary

What is the purpose of this trial?

The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable predictive models for osteoarthritis risk based on measures of post treatment contact stress, both to inform treatment and so that new interventions can be tested in a manner incorporating risk stratification.

Research Team

J L Marsh, MD

Principal Investigator

University of Iowa

Eligibility Criteria

This trial is for people aged 18-70 who need surgery after an ankle fracture involving the tibial plafond and can start treatment within 4 weeks of injury. Pregnant women or those planning pregnancy, and individuals outside this age range cannot participate.

Inclusion Criteria

I am seeking treatment within a month of my injury.

I am recommended for surgery.

I have had a fracture inside my ankle joint.

Exclusion Criteria

I am between 18 and 70 years old.

I am not pregnant and not planning to become pregnant.

Treatment Details

Interventions

• pedCAT (Radiation)

Trial Overview The study is evaluating a new standing CT scanner called pedCAT that may detect early joint degeneration and stress in weight-bearing poses better than current methods. It aims to improve osteoarthritis risk prediction post-injury.

Participant Groups

Group I: Experimental: pedCAT Experimental Treatment 1 Intervention

Subjects in this group will undergo weight-bearing CT (pedCAT) imaging at 6 months, 12 months, and 18 months post-ankle injury.

Who Is Running the Clinical Trial?

J L Marsh

Lead Sponsor

Trials

2

Recruited

30+

Orthopaedic Trauma Association

Collaborator

Trials

34

Recruited

5,100+