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Neurofeedback for Anxiety Disorders

N/A
Recruiting
Led By Stefanie Russman Block, Ph.D
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Primary diagnosis of generalized anxiety disorder, social anxiety disorder, panic disorder, or illness anxiety disorder based on structured interview
For females, not currently pregnant or actively trying to become pregnant
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 60 minutes
Awards & highlights
No Placebo-Only Group

Summary

This trial hopes to use brain scans to understand how feedback about our own brain activity can help us better regulate emotions. It may lead to better outcomes from psychotherapy in the future.

Who is the study for?
This trial is for individuals with a primary diagnosis of generalized anxiety disorder, social anxiety disorder, panic disorder, or illness anxiety disorder. Participants must be able to consent and tolerate small spaces without anxiety. They should not be on any psychotropic medication except stable antidepressants or birth control, and cannot be pregnant or trying to conceive. No metal implants that affect MRI.
What is being tested?
The study tests if real-time fMRI neurofeedback (Veritable-NF) can improve emotion regulation in anxious individuals compared to fake feedback (Sham-NF). It measures changes in brain activity and cognitive reappraisal ability—the skill of altering emotional responses by rethinking situations.
What are the potential side effects?
Since the interventions involve non-invasive fMRI scans with either real or sham neurofeedback, there are minimal side effects expected beyond the usual risks associated with MRIs such as discomfort from lying still and loud noises during scanning.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with an anxiety disorder.
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I am not pregnant or trying to conceive.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 60 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 60 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in negative affect ratings of images from International Affective Picture System (IAPS)
Secondary study objectives
Change in amygdala-PFC functional connectivity (baseline to transfer) from reappraise > look contrast

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Veritable-NFExperimental Treatment1 Intervention
Group II: Sham-NFActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Brain & Behavior Research FoundationOTHER
62 Previous Clinical Trials
2,891 Total Patients Enrolled
University of MichiganLead Sponsor
1,857 Previous Clinical Trials
6,437,654 Total Patients Enrolled
Stefanie Russman Block, Ph.DPrincipal InvestigatorUniversity of Michigan
1 Previous Clinical Trials
110 Total Patients Enrolled
~15 spots leftby Jul 2025
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