Endurance Exercise for Obesity
(ATLAS Trial)
Recruiting in Palo Alto (17 mi)
+1 other location
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: AdventHealth Translational Research Institute
Must not be taking: Beta blockers, Anticoagulants, Antipsychotics, others
Disqualifiers: Diabetes, Hypertension, Cardiovascular conditions, others
No Placebo Group
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?
The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.
Will I have to stop taking my current medications?
The trial does not specify if you must stop taking your current medications, but certain medications are exclusionary, such as those for cardiovascular, psychiatric, pulmonary, hormonal, and other conditions. If you are on any of these medications, you may not be eligible to participate.
What data supports the effectiveness of the treatment Endurance Exercise, Aerobic Exercise, Cardiovascular Exercise for obesity?
Is endurance exercise safe for people with obesity?
How does endurance exercise as a treatment for obesity differ from other treatments?
Endurance exercise, like aerobic or cardiovascular exercise, is unique because it not only helps with weight loss but also improves heart and muscle health, increases metabolism, and enhances glucose regulation. Unlike some treatments that focus solely on diet or medication, endurance exercise offers a holistic approach by improving overall fitness and reducing risks associated with obesity-related conditions.5681112
Eligibility Criteria
This trial is for men and pre-menopausal women aged 18-45 with obesity (BMI of 30.0-40.0), leading a sedentary lifestyle, who haven't had significant weight or lifestyle changes recently. Participants must understand English, agree to use birth control if applicable, and commit to the study's procedures.Inclusion Criteria
BMI 30.0-40.0 kg/m2
For women not using pharmaceutical contraception, must agree to use specified birth control methods
Sedentary lifestyle defined as minimal exercise in the past year
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Exclusion Criteria
Unstable body weight in the last 3 months
Significant changes in diet or physical activity in the last 3 months
Weight >396 lb (180 kg)
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Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants undergo endurance exercise training or control (no exercise) for 12 weeks
12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Treatment Details
Interventions
- Endurance Exercise (Behavioural Intervention)
Trial OverviewThe study investigates how endurance exercise affects fat tissue quality and insulin sensitivity in obese individuals. It involves muscle and fat biopsies, heavy water labeling, glucose clamp tests, monitoring physical activity/dietary habits using an accelerometer.
Participant Groups
2Treatment groups
Active Control
Group I: Endurance exercise (EX) groupActive Control6 Interventions
Group II: Control (CTRL) groupActive Control6 Interventions
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
AdventHealth Translational Research InstituteOrlando, FL
Pennington Biomedical Research CenterBaton Rouge, LA
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Who Is Running the Clinical Trial?
AdventHealth Translational Research InstituteLead Sponsor
Pennington Biomedical Research CenterCollaborator
References
Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial. [2022]Aerobic exercise is an important part of obesity treatment and may improve health-related quality of life (HRQOL). The objective of this study was to compare the effect of two different exercise programs on health-related quality of life in patients with severe obesity.
Physical activity in management of persons with obesity. [2021]Physical activity and exercise have many benefits in persons with obesity, helping with weight loss, body fat loss, abdominal visceral fat loss and possibly with weight maintenance after weight loss. The effect of exercise training (endurance or endurance plus resistance or high-intensity interval training) alone on weight loss as outcome appears relatively modest, amounting to only a few kg. However, endurance training during weight loss has been shown to increase V̇O2max and resistance training during weight loss leads to lower loss in lean body mass and increased muscle strength. In addition, higher physical activity levels improve cardiovascular risk, whatever weight variations. Specifically, physical activity or exercise is part of lifestyle measures for prevention of type 2 diabetes and substantially helps with metabolic control in patients with type 2 diabetes. The importance of physical activity counselling and exercise prescription in the management strategy will depend on specific treatment objectives as defined for a given patient, including weight loss, prevention of weigh regain, prevention of cardio-metabolic comorbidities, lean body mass preservation but also improvement in quality of life or development of social links. The 5 A's strategy consisting in: Ask, Assess, Advise, Agree, Assist (or Arrange) appears well adapted in this setting. Professionals need to be aware of the many barriers patients with obesity may meet on their way to increase habitual physical activity as specific solutions should be proposed. A major challenge is how to improve adherence to new physical activity habits over time.
Usefulness of an Easy, Structured, and Home-Based Exercise Program to Improve Physical Performance and Quality of Life in a Patient's Cohort with Obesity. [2023]The benefits of exercise in patients with obesity are clear; physical performance and quality of life improve after exercise programs in patients with obesity. Our aim was to evaluate the usefulness of an easy, structured, and home-based exercise program to improve physical performance and quality-of-life in patients with obesity.
Physical activity, diet and behaviour modification in the treatment of overweight and obese adults: a systematic review. [2018]The aim was to extend the body of knowledge through a systematic review that combines the strengths and partly fills the gaps from earlier reviews. The aim is to review randomized controlled trials of the long-term effectiveness of physical exercise/activity with or without diet and/or behaviour modification therapy in terms of training effect, weight loss and improvement of body composition in overweight and obese, healthy adults.
More exercise for the obese? [2006]Increased physical activity has usually not been considered a successful means to treat obesity because of the small and slowly occurring weight loss and bad compliance with exercise programs. Exercise has been advocated because it prevents the loss of fat-free tissues induced by hypocaloric diets. Muscular work may also elevate the metabolic rate for some hours after the cessation of exercise, but this requires high-intensity exercise. Instead, aerobic exercise may have more importance in ameliorating metabolic and hemodynamic disturbances often associated with obesity. Aerobic exercise of moderate intensity may increase serum high-density and decrease very-low-density lipoproteins, decrease serum insulin, and decrease blood pressure, especially during exertion. Similar alterations may also be achieved with a prudent diet alone, but inclusion of exercise provides more possibilities to vary the diet. A multifactorial approach (nutrition education, behavior modification and exercise) is needed to improve adherence to diet in mild and moderate obesity and to maintain weight loss. More than a formal physical exercise program for a couple of months, the obese need to include physical activity permanently as a part of everyday life.
Muscle FOXO-Specific Overexpression and Endurance Exercise Protect Skeletal Muscle and Heart from Defects Caused by a High-Fat Diet in Young Drosophila. [2023]Obesity appears to significantly reduce physical activity, but it remains unclear whether this is related to obesity-induced damage to skeletal muscle (SM) and heart muscle (HM). Endurance exercise (EE) reduces obesity-induced defects in SM and HM, but its molecular mechanism is poorly understood.
Physical exercise and morbid obesity: a systematic review. [2019]Physical exercise is an important component for the treatment of obesity. Little information is available about the best and safety form of physical exercise concerning the type and volume-intensity to be prescribed for individuals with morbid obesity.
Eight sessions of endurance training decrease fasting glucose and improve glucose tolerance in middle-aged overweight males. [2021]Exercise improves metabolic regulation and reduces the risk of developing type 2 diabetes and other metabolic diseases. The recommendations for exercise are rather general and the health benefits of controlled training studies are important to make better recommendations. In the present study, we report that eight endurance training sessions over 3 weeks reduced fasting glucose, and improved glucose tolerance and plasma lipids in sedentary middle-aged males (44-64 years) with overweight or obesity (BMI: 27-38). The decrease in fasting glucose was substantial (from 5.3 ± 0.3 to 4.8 ± 0.2 mM; p < .001). The training sessions consisted of 60-min indoor-cycling at ∼83% of peak heart rate divided in four blocks of 15 min cycling, with 2-min rest between blocks. Maximal oxygen uptake did not increase (38.8 ± 1.8 vs. 39.0 ± 1.6 ml kg-1 min-1). In conclusion, 3-weekly sessions of moderate-/high-intensity endurance training can be recommended for untrained males with overweight or obesity to improve glucose homeostasis.
Evaluation of exercise prescription for hypertensive obese men by ventilatory threshold. [2019]Prescription of aerobic exercise for obese subjects with mild hypertension in clinical practice remains to be investigated.
Influences of Resistance versus Aerobic Exercise on Physiological and Physical Fitness Changes in Previously Inactive Men with Obesity: A Prospective, Single-Blinded Randomized Controlled Trial. [2022]The purpose of this study was to comparatively investigate changes in physiological and physical fitness in previously inactive men with obesity in response to aerobic exercise (AE) or resistance exercise (RE).
Special ergometric techniques and weight reduction. [2013]Several physiological and psychological benefits can be achieved with exercise training provided an adequate exercise threshold is reached. In recommending exercise regimens to obese individuals, it is important to consider the exercise intensity, frequency, and duration that is most likely to lead to the desired benefits of exercise training. The special problems that some obese individuals may encounter with exercise training should also be considered. Walk/jog and stationary cycling are the two most commonly recommended modes of exercise. Aquatic exercise, due to the buoyancy and thermal properties of water, may be especially suitable as a method of exercise for obese individuals. In addition to swimming, cycling exercise and aerobic dance can be performed in a water environment.
Exercise physiology and cardiovascular fitness. [2008]Endurance exercise training produces numerous metabolic and cardiovascular effects. Metabolic adaptations include an increase in oxidative capacity of skeletal muscle (greater number and size of mitochondria); an increase in skeletal muscle myoglobin concentration; a greater ability to oxidize fatty acids for energy; and an increase in stored glycogen. Cardiovascular effects of training include a decrease in resting heart rate and heart rate response to submaximal exercise; an increase in resting and exercise stroke volume; an increase in maximal cardiac output; an increase in VO2max; and an increase in arteriovenous oxygen difference. Aerobic exercise training contributes to cardiovascular fitness, because it beneficially alters the coronary artery disease risk profile. An inverse relationship exists between physical fitness and resting heart rate, body weight, percent body fat, serum cholesterol, triglycerides, glucose, and systolic blood pressure. In addition, exercise training increases the high-density lipoprotein fraction of total cholesterol. Endurance exercise is any activity that uses large muscle groups, can be performed continuously, and is rhythmic and aerobic in nature. To develop and maintain cardiovascular fitness, this exercise should be performed at a frequency of 3 to 5 days per week, an intensity of 60% to 90% HRmax or 50% to 85% HRmax reserve, and a duration of 20 to 60 minutes.