What side effects are associated with this type of intervention?

Common treatments for aphasia, including those similar to implicit priming techniques, generally have minimal physical side effects. The primary side effects are cognitive fatigue and frustration due to the intensive mental effort required. These treatments focus on enhancing language abilities through repetitive practice and cognitive exercises, which can be mentally exhausting for patients. It is important for patients to work closely with their therapists to manage these side effects and ensure a balanced approach to therapy.

What prior FDA approvals exist?

Currently, there are no FDA-approved drugs specifically for the treatment of aphasia. Treatment typically involves speech and language therapy, which can include various techniques such as implicit priming, where subconscious cues are used to enhance sentence production and comprehension. Research is ongoing to develop and validate new therapeutic approaches, including the use of implicit priming methods.

What other types of research exist?

Promising novel alternatives to implicit priming for aphasia treatment include: 1) Transcranial Direct Current Stimulation (tDCS), which has shown potential in improving language functions by modulating neural activity. 2) Intensive Language Action Therapy (ILAT), also known as Constraint-Induced Aphasia Therapy (CIAT), which focuses on intensive practice and use of verbal communication. 3) Virtual Reality (VR)-based therapies, which provide immersive environments for practicing language skills. 4) Computer-based language training programs that offer personalized and adaptive exercises to improve language abilities.

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Sentence Training for Aphasia

N/A

Recruiting

Led By Jiyeon Lee, PhD

Research Sponsored by Purdue University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Normal or corrected to normal hearing and vision

Be older than 18 years old

Must not have

Severe apraxia of speech

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from baseline up to 1-week post training or 2-month post treatment

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to improve sentence production and comprehension in people with aphasia using a technique that subtly influences the brain to enhance language skills without the person being fully aware of it. The goal is to create lasting improvements in language abilities by frequently exposing the brain to certain language patterns.

Who is the study for?

This trial is for English-speaking adults who had a stroke in the left hemisphere of their brain at least 6 months ago, causing aphasia. They should have completed high school and have normal or corrected vision and hearing. Participants must struggle with forming sentences but can use some words independently. Those with uncontrolled mental health issues, substance abuse, severe speech apraxia, or other neurological conditions affecting communication cannot join.

What is being tested?

The study is testing a new method to improve sentence formation and understanding in people with aphasia using 'implicit priming'. Researchers will first identify the most effective priming conditions for learning enhancement before developing and evaluating a novel treatment based on these initial findings.

What are the potential side effects?

Since this intervention involves language training exercises rather than medication or invasive procedures, traditional physical side effects are not expected. However, participants may experience fatigue or frustration during the learning process.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My hearing and vision are normal, or corrected to be normal.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have severe difficulty speaking clearly.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from baseline up to 1-week post training or 2-month post treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from baseline up to 1-week post training or 2-month post treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline up to 1-week post training or 2-month post treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Comprehension of target sentences in a sentence-to-picture matching task

Production of target sentences on action description pictures

Real-time comprehension of target sentences in a sentence-to-picture matching task

Secondary study objectives

Connected speech production - picture description

Connected speech production - story retell

Production of untrained sentences on action describing pictures

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Structural priming trainingExperimental Treatment1 Intervention

Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each session. In experiment 4, participants will receive a structural priming treatment in a single-subject design.

0 / 2Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Implicit priming for Aphasia treatment uses subconscious cues to enhance sentence production and comprehension by leveraging the brain's residual language abilities. This method involves repeated exposure to specific linguistic patterns, helping to reactivate and strengthen neural pathways associated with language. This approach is important for Aphasia patients as it offers a non-invasive and potentially more natural way to regain language skills, improving their communication abilities and overall quality of life.

Increasing aphasia treatment intensity in an acute inpatient rehabilitation program: A feasibility study.Evaluation of lexically and nonlexically based reading treatment in a deep dyslexic.