tACS for Aphasia After Stroke
PS
Overseen byPriyanka Shah-Basak, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Medical College of Wisconsin
No Placebo Group
Trial Summary
What is the purpose of this trial?
This study is evaluating whether a type of electrical stimulation may help improve language recovery for individuals who have had a stroke.
Research Team
PS
Priyanka Shah-Basak, PhD
Principal Investigator
Medical College of Wisconsin
Eligibility Criteria
This trial is for adults who have had a stroke and are experiencing language difficulties (aphasia), as well as healthy adults without neurological issues. Participants must be fluent in English, at least 18 years old, and right-handed if they've had a stroke. They can't join if they have severe sensory impairments, untreated psychiatric diseases, unstable medical conditions, metal implants in the skull, or history of seizures or dyslexia.Inclusion Criteria
I am fluent in English.
Healthy Controls: Fluent in English
I have never had a neurological or psychiatric disorder.
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Exclusion Criteria
I have a history of seizures.
You have conditions that make it unsafe for you to have an MRI or tACS.
You have serious problems with thinking, hearing, or seeing that would make it difficult to do tests related to thinking and language.
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Treatment Details
Interventions
- tACS 10-Hz (Behavioural Intervention)
- tACS 40-Hz (Behavioural Intervention)
- tACS sham (Behavioural Intervention)
Trial OverviewThe study is testing three types of transcranial alternating current stimulation (tACS): one with a frequency of 10-Hz, another with 40-Hz, and a sham (placebo) treatment to see how they affect language recovery after stroke and general language functions.
Participant Groups
3Treatment groups
Experimental Treatment
Placebo Group
Group I: tACS 40 Hz high frequencyExperimental Treatment1 Intervention
High-Definition-tACS will be delivered via a battery operated alternating current stimulator (Soterix) using two 3x1 center-surround montages. Targets of stimulation will be localized based on the 10-10 International EEG system with center electrodes placed at a frontal and a temporoparietal site. The current is turned on and increased in a ramplike fashion over approximately 30 seconds. Participants will undergo tACS with 40-Hz stimulation for 20-minutes with 1 milliampere (mA) peak-to-peak intensity. Stimulation will be maintained no longer than 20 minutes.
Group II: tACS 10 Hz low frequencyExperimental Treatment1 Intervention
High-Definition-tACS will be delivered via a battery operated alternating current stimulator (Soterix) using two 3x1 center-surround montages. Targets of stimulation will be localized based on the 10-10 International EEG system with center electrodes placed at a frontal and a temporoparietal site. The current is turned on and increased in a ramplike fashion over approximately 30 seconds. Participants will undergo tACS with 10-Hz stimulation for 20-minutes with 1 milliampere (mA) peak-to-peak intensity. Stimulation will be maintained no longer than 20 minutes.
Group III: tACS shamPlacebo Group1 Intervention
High-Definition-tACS will be delivered via a battery operated alternating current stimulator (Soterix) using two 3x1 center-surround montages. Targets of stimulation will be localized based on the 10-10 International EEG system with center electrodes placed at a frontal and a temporoparietal site. The current is turned on and increased in a ramplike fashion for 10 to 30 seconds and then ramped down. In this way, the participants experience the same initial sensations (mild tingling) as the active tACS groups.
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Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor
Trials
645
Recruited
1,180,000+