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Behavioural Intervention

Multicomponent Language Treatment for Primary Progressive Aphasia

N/A
Waitlist Available
Led By Maya L Henry, PhD
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must not have
Significant, uncorrected visual or hearing impairment that would interfere with participation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-treatment (approximately 6-12 weeks after treatment onset)
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to help individuals with Primary Progressive Aphasia (PPA), a condition that causes a gradual decline in communication skills due to brain degeneration. The researchers want to test a new treatment approach

Who is the study for?
This trial is for adults diagnosed with Primary Progressive Aphasia (PPA) who can still score at least 10 on the Mini-Mental State Examination. They must have a partner to attend sessions with them. It's not suitable for those with major visual/hearing issues, other cognitive/behavioral/motor impairments, or additional neurological/psychiatric conditions affecting language skills.
What is being tested?
The study tests three treatments: Multi-LRT focuses on word finding strategies; Multi-VISTA uses video scripts to improve speech; and Multi-CPT involves partners in communication training. The goal is to see if these combined approaches help maintain language functions and quality of life in PPA patients.
What are the potential side effects?
Since this trial involves behavioral interventions like language training rather than medication, traditional side effects are not expected. However, participants may experience fatigue or frustration during therapy sessions.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I do not have major vision or hearing problems that would affect my participation.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in script production accuracy
Change in spoken naming of trained/untrained items
Goal Attainment Score
+1 more
Secondary study objectives
Change on Aphasia Impact Questionnaire
Change on Quick Aphasia Battery
Other study objectives
Post-treatment Communication Survey

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)Experimental Treatment1 Intervention
Group II: Multicomponent Lexical Retrieval Training (Multi-LRT)Experimental Treatment1 Intervention
Group III: Multicomponent Communicaiton Partner Training (Multi-CPT)Experimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
374 Previous Clinical Trials
86,154 Total Patients Enrolled
1 Trials studying Progressive Aphasia
120 Patients Enrolled for Progressive Aphasia
Maya L Henry, PhDPrincipal InvestigatorUniversity of Texas - Austin
1 Previous Clinical Trials
60 Total Patients Enrolled
~5 spots leftby May 2025