Anti-Inflammatory Diet for Rheumatoid Arthritis
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of California, San Diego
Disqualifiers: Pregnancy, Food allergies, others
No Placebo Group
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?This trial is testing whether an anti-inflammatory diet can improve symptoms in people with rheumatoid arthritis. The diet includes foods that help reduce inflammation. Researchers are also studying how this diet changes gut bacteria and substances in the blood.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if your medication use might make it hard to interpret the study results, you may not be eligible to participate.
What data supports the effectiveness of the Anti-inflammatory Diet, Mediterranean Diet, and Anti-inflammatory Dietary Approach treatment for Rheumatoid Arthritis?
Research suggests that the Mediterranean diet, which is part of the anti-inflammatory dietary approach, may help reduce disease activity and improve pain in people with rheumatoid arthritis, although the evidence is not very strong. Some studies have shown improvements in joint pain and swelling when following this diet compared to a regular Western diet.
12345Is the anti-inflammatory diet, like the Mediterranean diet, safe for humans?
The Mediterranean diet, often used as an anti-inflammatory diet, is generally considered safe for humans and has been studied for its potential benefits in managing conditions like rheumatoid arthritis.
13467How is the anti-inflammatory diet treatment different from other treatments for rheumatoid arthritis?
The anti-inflammatory diet, specifically the Mediterranean diet, is unique because it focuses on dietary changes rather than medication, aiming to reduce inflammation through foods rich in healthy fats, fruits, and vegetables. This approach is different from standard drug treatments, which typically involve medications to manage symptoms and inflammation.
12347Eligibility Criteria
This trial is for individuals with low to moderate rheumatoid arthritis who haven't changed their treatment or disease activity in the last 3 months. They should be interested in dietary changes and able to attend follow-up visits. It's not for those with food allergies, pregnant or nursing women, or anyone with other health issues that could confuse the results.Inclusion Criteria
You have mild or moderate symptoms of the condition being studied, and have not had any changes in treatment or symptoms for the last 3 months. You are willing to try a new diet and can attend all follow-up appointments.
Exclusion Criteria
You have allergies to certain types of food.
Pregnancy or lactating. Patients that will become pregnant during the study will be remove from the study.
You have other health conditions or take medications that could make it hard for the doctor to understand the study results.
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants follow an anti-inflammatory diet to assess its effect on rheumatoid arthritis outcomes, microbiome, and circulating metabolites
12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study tests two anti-inflammatory diets to see if they improve symptoms of rheumatoid arthritis. Researchers will also look at how these diets might change gut bacteria and body chemicals related to inflammation.
2Treatment groups
Experimental Treatment
Active Control
Group I: Arm_2Experimental Treatment1 Intervention
Anti-Inflammatory diet 2
Group II: Arm_1Active Control1 Intervention
Anti-inflammatory diet 1
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
UCSDLa Jolla, CA
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Who Is Running the Clinical Trial?
University of California, San DiegoLead Sponsor
References
Dietary Pattern or Weight Loss: Which One Is More Important to Reduce Disease Activity Score in Patients with Rheumatoid Arthritis? A Randomized Feeding Trial. [2023]Label="Objectives" NlmCategory="UNASSIGNED">Herein, disease activity score 28 (DAS 28) was compared between patients with rheumatoid arthritis (RA) receiving the Mediterranean dietary pattern (MD) and low-fat diet. Subjects/Methods. Overweight and obese RA patients aged 15-75 y participated in this randomized feeding trial. Participants were randomized to MD (n = 51) and low-fat high-carbohydrate diet (n = 53) for 12 weeks. The control group followed their regular diet (n = 50). Participants completed the form of tender and swollen joint counts before the study enrollment and after 12 weeks to compute DAS 28.
An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. [2022]To investigate the efficacy of a Mediterranean diet (MD) versus an ordinary Western diet for suppression of disease activity in patients with rheumatoid arthritis (RA).
Let Food Be Thy Medicine: The Case of The Mediterranean Diet in Rheumatoid Arthritis. [2020]The role of diet in rheumatoid arthritis (RA) has been the topic of extensive research. The present review aimed to present and appraise the studies assessing adherence to the Mediterranean diet (MD) and the primary/secondary prevention of rheumatoid arthritis. Based on the available studies, the evidence appears low and adherence to the MD does not appear to affect RA indices.
The effects of the Mediterranean diet on rheumatoid arthritis prevention and treatment: a systematic review of human prospective studies. [2019]Rheumatoid arthritis is a progressive autoimmune disease characterised by severely swollen and painful joints. To compliment pharmacotherapy, people living with rheumatoid arthritis often turn to dietary interventions such as the Mediterranean diet. The aim of the present systematic review is to discuss the effects of the Mediterranean diet on the management and prevention of rheumatoid arthritis in human prospective studies. Four studies met the inclusion criteria, including two intervention studies reporting improvement in the pain visual analogue scale (p
The Mediterranean diet, and not dietary inflammatory index, is associated with rheumatoid arthritis disease activity, the impact of disease and functional disability. [2023]To assess the relationship between adherence to the Mediterranean Diet (MD) /individual Dietary Inflammatory Index (DII) and disease activity, disease impact, and functional status in Rheumatoid Arthritis (RA) patients.
Mediterranean diet and incidence of rheumatoid arthritis in women. [2022]We examined the association between a Mediterranean dietary pattern, as measured by the Alternate Mediterranean Diet Score (aMed), and risk of incident rheumatoid arthritis (RA) in US women.
Effects of Mediterranean diet on the treatment of rheumatoid arthritis. [2020]It has been suggested that environmental and lifestyle factors might contribute to the severity and progression of inflammation in rheumatoid arthritis. An intervention generating high interest due to its supposed anti-inflammatory properties is the Mediterranean diet.