Exercise Intensity and Balance Training for Spinocerebellar Ataxia

(PRIME-Ataxia Trial)

Overseen by Chelsea E Macpherson, DPT

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Teachers College, Columbia University

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial is testing two different online exercise routines for people with spinocerebellar ataxias (SCAs). One routine involves intense cardio workouts before balance exercises, while the other involves light exercises like stretching before balance exercises. The goal is to see which routine better improves balance and motor skills in people with SCAs.

Research Team

Lori Quinn, PT, EdD

Principal Investigator

Teachers College, Columbia University

Chelsea E Macpherson, DPT

Principal Investigator

Teachers College, Columbia University

Eligibility Criteria

This trial is for people aged 18-85 with a confirmed genetic diagnosis of Spinocerebellar Ataxia types SCA1, 2, 3, 6, or 7. Participants should have mild to moderate disease severity and be able to walk with or without help. They need a care partner available during sessions and must not have been doing intense exercise recently.

Inclusion Criteria

My ataxia is mild to moderate, with a SARA score between 8-25.

I can walk, with or without help from a device.

My condition is genetically confirmed as SCA1, 2, 3, 6, or 7.

Exclusion Criteria

My heart or lung condition doesn't limit my ability to exercise.

You have confirmed loss of feeling in your hands or feet.

I have severe vision problems due to my ataxia.

Treatment Details

Interventions

• High-Intensity Aerobic Exercise Prior to Balance Training (Behavioral Intervention)
• Low-Intensity Exercise Prior to Balance Training (Behavioral Intervention)

Trial Overview The PRIME-Ataxia study tests if high-intensity aerobic exercise before balance training is more effective than low-intensity exercise for the same purpose in individuals with SCAs. This telehealth program runs for eight weeks and includes an assessment of motor skill learning.

Participant Groups

Group I: Group 1 Experimental Treatment 1 Intervention

High-Intensity Aerobic Exercise Prior to Balance Training

Group II: Group 2 Active Control 1 Intervention

Low-Intensity Exercise Prior to Balance Training

Who Is Running the Clinical Trial?

Teachers College, Columbia University

Lead Sponsor

Trials

27

Recruited

6,100+