~15 spots leftby Jan 2026

Time-Restricted Eating + Calorie Restriction for Weight Loss and Bone Health (TREMBO Trial)

Palo Alto (17 mi)
Age: 18+
Sex: Female
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: N/A
Waitlist Available
Sponsor: Rutgers, The State University of New Jersey
No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a diet where older women who are overweight or obese eat only during certain times and reduce their calorie intake. The goal is to see if this helps them lose weight, improve heart health, and strengthen bones by changing gut bacteria.

Eligibility Criteria

This trial is for postmenopausal women who are overweight or obese, with a BMI of 25-39 kg/m2 and eat over a span of at least 14 hours daily. They must be able to visit the site in New Brunswick, NJ without travel reimbursement. Women taking certain bone medications, those with recent significant weight loss or extreme diets, smokers, and those with various health conditions including uncontrolled hypertension cannot participate.

Treatment Details

The TREMBO study is testing if eating within a set time frame each day plus cutting calories helps older women lose weight better than just cutting calories alone. It also looks at how this might affect the good bacteria in their guts and their bone health.
2Treatment groups
Experimental Treatment
Active Control
Group I: Time restricted eating and calorie restrictionExperimental Treatment2 Interventions
Subjects will be asked to adhere to a calorie-restricted diet and will be counseled by a dietitian for diet and lifestyle behavior education. In addition, they will be asked to only consume calories during a 9-hour window (15:9).
Group II: Calorie restriction aloneActive Control1 Intervention
Subjects will be asked to adhere to a calorie-restricted diet and will be counseled by a dietitian for diet and lifestyle behavior education. They will be advised to continue to consume foods throughout the day and into the evening.

Find a clinic near you

Research locations nearbySelect from list below to view details:
Sue A ShapsesNew Brunswick, NJ
Rutgers University - NJ Inst Food Nutrition & HealthNew Brunswick, NJ
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Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor

References