What side effects are associated with this type of intervention?

Common treatments for breast cancer, including radiation therapy, chemotherapy, and surgery, have various side effects. Radiation therapy can cause acute toxicity, skin reactions, and changes in breast appearance. Chemotherapy may lead to immunosuppression, gastrointestinal issues, fatigue, and hair loss. Surgical interventions can result in pain, scarring, and potential infections. Hormone therapy, used for hormone receptor-positive cancers, can cause hot flashes, vaginal dryness, and an increased risk of blood clots. Side effects vary depending on the treatment and individual patient response.

What prior FDA approvals exist?

The FDA has approved several targeted therapies for breast cancer, particularly for HER2-positive cases. Trastuzumab, often combined with other agents like pertuzumab or lapatinib, has shown significant efficacy. Additionally, endocrine therapies are used for hormone receptor-positive breast cancer. Imaging techniques, including advanced ultrasound methods, play a crucial role in the diagnosis and management of breast cancer, aiding in the detection and characterization of breast masses.

What other types of research exist?

Promising novel alternatives to the new ultrasound imaging method for breast cancer diagnosis in 2024 include: 1) MRI, which is highly effective in detecting breast implant ruptures and occult primary breast carcinoma; 2) Elastography, particularly shear-wave elastography, which improves the specificity of breast ultrasound; and 3) PET/CT scans, which provide metabolic information and can detect otherwise occult metastatic disease. These technologies offer advanced diagnostic capabilities and may complement or serve as alternatives to traditional ultrasound imaging.

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3D Ultrasound Imaging for Breast Cancer Detection

Q: What is the mechanism of action of this treatment?

Common treatments for breast cancer include surgery, which physically removes the tumor; radiation therapy, which uses high-energy rays to kill cancer cells; chemotherapy, which uses drugs to destroy rapidly dividing cells; hormone therapy, which blocks hormones that fuel certain cancers; and targeted therapy, which attacks specific molecules involved in cancer growth. Understanding these mechanisms helps patients and doctors choose the most effective treatment plan, especially when new diagnostic tools like 3D ultrasound imaging can provide more accurate detection and characterization of breast masses, potentially leading to more personalized and effective treatment strategies.

N/A

Recruiting

Led By Shigao Chen, Ph.D.

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult women, ≥ 18 years of age.

Be older than 18 years old

Must not have

< 18 years of age.

Lacking capacity to consent.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a new ultrasound method to better diagnose breast lumps by creating clearer and more detailed images.

Who is the study for?

This trial is for adult women over 18 with a breast lesion who are scheduled for a biopsy. It's not open to those under 18, anyone with previous breast surgery or implants, those unable to consent, pregnant or breastfeeding women, or patients currently undergoing cancer treatments.

What is being tested?

The study is testing the effectiveness of a new ultrasound imaging method using two different scanners: the GE Logiq E10 and the Verasonics research scanner. The goal is to see how well they diagnose breast masses compared to current methods.

What are the potential side effects?

Ultrasound scanning is generally safe and does not have significant side effects. However, there might be minor discomfort due to pressure from the ultrasound probe during imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a woman aged 18 or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am under 18 years old.

Select...

I am unable to understand or make decisions about my treatment.

Select...

I have had breast surgery or have a breast implant.

Select...

I am currently undergoing cancer treatment like chemotherapy or radiation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

BI-RADS Score

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Clinically indicated breast tumor biopsyExperimental Treatment2 Interventions

Subjects with breast lesion and are scheduled for clinically-indicated biopsy will have 3D Multimodal Ultrasound Imaging performed

0 / 5Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for breast cancer include surgery, which physically removes the tumor; radiation therapy, which uses high-energy rays to kill cancer cells; chemotherapy, which uses drugs to destroy rapidly dividing cells; hormone therapy, which blocks hormones that fuel certain cancers; and targeted therapy, which attacks specific molecules involved in cancer growth. Understanding these mechanisms helps patients and doctors choose the most effective treatment plan, especially when new diagnostic tools like 3D ultrasound imaging can provide more accurate detection and characterization of breast masses, potentially leading to more personalized and effective treatment strategies.

Impact of modern personalized treatment of breast cancer on surgical attitude and outcomes.