Trial Summary
What is the purpose of this trial?The purpose of this is to determine the efficacy and toxicity of proton therapy when used to deliver partial breast radiotherapy in patients with early stage breast cancer with low or intermediate risk factors.
Eligibility Criteria
This trial is for women aged 40 or older with early stage breast cancer that's low or intermediate risk. The tumor must be no larger than 3 cm, and they should have had a lumpectomy with clip placement and axillary node sampling showing negative margins. Women can't join if they are pregnant, breastfeeding, have certain genetic mutations like BRCA, active collagen vascular disease, distant spread of cancer (metastasis), more than one center of cancer in the same breast (multicentric disease), or previous radiation/chemotherapy.Inclusion Criteria
I have been diagnosed with ductal carcinoma in situ (DCIS).
I am 40 years old or older.
I have been diagnosed with breast cancer.
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Exclusion Criteria
My cancer has spread to my lymph nodes beyond a microscopic level.
My cancer has spread to distant parts of my body.
Pregnant or lactating
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Participant Groups
The trial is testing how effective and safe proton beam radiotherapy is when used as partial breast treatment in patients with early stage breast cancer. Proton therapy is a type of radiation that targets tumors more precisely to minimize damage to surrounding healthy tissue.
1Treatment groups
Experimental Treatment
Group I: Partial Breast Proton TherapyExperimental Treatment1 Intervention
Two weeks of daily proton therapy delivered to the lumpectomy site.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Loma Linda University Medical Center / James M. Slater MD Proton Treatment Center / Department of Radiation Medicine / 11234 Anderson St.Loma Linda, CA
Loma Linda University Medical CenterLoma Linda, CA
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Who Is Running the Clinical Trial?
Loma Linda UniversityLead Sponsor