~4 spots leftby Apr 2026

Intracardiac Echocardiography for Hypertrophic Cardiomyopathy

Recruiting in Palo Alto (17 mi)
Overseen byDaniel Swistel, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: NYU Langone Health
No Placebo Group

Trial Summary

What is the purpose of this trial?

This is a follow up investigation to our previous study entitled "On-pump intraoperative echocardiography (OPIE)" (clinicaltrials.gov NCT03094325) whereby we determined that left ventricular septal thickness as measured by the OPIE technique correlates highly with traditional methods of transthoracic and transesophageal echocardiography during septal myectomy for hypertrophic cardiomyopathy. OPIE may be especially useful in patients with a thin ventricular septal thickness as adequate treatment may rely on mere millimeters of myocardial resection. We therefore propose a study in which OPIE is compared to transthoracic and transesophageal echocardiography in patients with a thin interventricular septum. Subjects will receive the same perioperative care regardless of their involvement in the study. Patients who enroll in the study will undergo an additional intraoperative echocardiographic measurement that adds less than five minutes to total operative time.

Eligibility Criteria

This trial is for adults over 18 with hypertrophic cardiomyopathy scheduled for septal myectomy and have a thin interventricular septum (less than 2.0 cm wide) as shown by echocardiography. It's open to all genders and races.

Inclusion Criteria

I am over 18, have hypertrophic cardiomyopathy, and will have surgery to remove part of my heart muscle.

Exclusion Criteria

I am under 18 and scheduled for heart surgery due to thickened heart muscle.

Treatment Details

Interventions

  • On-pump Intracardiac Echocardiography (Diagnostic Device)
Trial OverviewThe study tests on-pump intracardiac echocardiography (OPIE) against traditional transthoracic and transesophageal methods in measuring ventricular septal thickness during surgery for those with a thin septum.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: OPIE in thin inverventricular septumExperimental Treatment1 Intervention
The Principal Investigator use the OPIE probe to measure the anterior basilar septal thickness. Myectomy will be performed and OPIE will be repeated.

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
NYU Langone HealthNew York, NY
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Who Is Running the Clinical Trial?

NYU Langone HealthLead Sponsor

References