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Device

Transcranial Magnetic Stimulation for Stroke (CAM Trial)

N/A
Recruiting
Led By George F. Wittenberg, MD PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be 45-90 years of age
Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
Must not have
Unable to give informed consent
Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediate (within 2 s after stimulation)
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether TMS can help people with stroke regain movement.

Who is the study for?
This trial is for English-speaking adults aged 45-90 who've had a stroke at least 6 months ago, resulting in mild to moderate arm dysfunction. They must be medically stable and have no serious illnesses that would affect participation. People with visual loss, joint motion issues, or conditions preventing safe TMS/MRI use cannot join.
What is being tested?
The study uses Transcranial Magnetic Stimulation (TMS) while participants make movements with a robotic arm device to understand how the brain controls movement before and after a stroke and when it's most responsive to TMS.
What are the potential side effects?
TMS may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in very rare cases. It's generally considered safe but should be avoided by those with certain medical implants.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 45 and 90 years old.
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I had a stroke in a deep part of my brain.
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I had a stroke that affects one side of my body and other causes have been ruled out.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am unable to understand and agree to the study's procedures and risks.
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I do not have joint or bone problems that limit my movement for study activities.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediate (within 2 s after stimulation)
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediate (within 2 s after stimulation) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Path length
Secondary study objectives
Accuracy
EMG
Times
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Reaching with TMSExperimental Treatment1 Intervention
All participants enrolled in this group will receive TMS while performing reaching movements in a robotic system.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
2017
Completed Phase 4
~730

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,668 Previous Clinical Trials
3,765,790 Total Patients Enrolled
86 Trials studying Stroke
6,804 Patients Enrolled for Stroke
VA Pittsburgh Healthcare SystemFED
34 Previous Clinical Trials
13,150 Total Patients Enrolled
2 Trials studying Stroke
2 Patients Enrolled for Stroke
University of PittsburghOTHER
1,792 Previous Clinical Trials
16,359,910 Total Patients Enrolled
28 Trials studying Stroke
2,825 Patients Enrolled for Stroke
George F. Wittenberg, MD PhDPrincipal InvestigatorVA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
1 Previous Clinical Trials
68 Total Patients Enrolled
1 Trials studying Stroke
68 Patients Enrolled for Stroke

Media Library

Transcranial Magnetic Stimulation (Device) Clinical Trial Eligibility Overview. Trial Name: NCT04286516 — N/A
Stroke Research Study Groups: Reaching with TMS
Stroke Clinical Trial 2023: Transcranial Magnetic Stimulation Highlights & Side Effects. Trial Name: NCT04286516 — N/A
Transcranial Magnetic Stimulation (Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04286516 — N/A
~6 spots leftby Jun 2025
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