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Walnuts for Cardiovascular Health
N/A
Waitlist Available
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
* Overweight and obese men and postmenopausal women between 45-70 years of age, BMI range of 25.0-39.9 kg/m2 and elevated LDL-C levels (130-189 mg/dL).
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 10 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial will test if eating walnuts has any effect on blood lipids and inflammation, as well as gut bacteria.
Who is the study for?
This trial is for overweight and obese men and postmenopausal women aged between 45-70, with a BMI of 25.0-39.9 kg/m2 and higher levels of 'bad' cholesterol (LDL-C between 130-189 mg/dL).
What is being tested?
The study is examining the effects of eating walnuts on heart health markers like good and bad cholesterol, inflammation in the blood, as well as gut bacteria compared to a no-nut diet.
What are the potential side effects?
Potential side effects from walnut consumption may include digestive discomfort or allergic reactions for those with nut allergies.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, an average of 10 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 10 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Lipids
Assessing the influence of walnut consumption on blood pressure.
Assessing the influence of walnut consumption on circulating inflammatory markers: PAI-1, VCAM-1 and ICAM-1.
Secondary study objectives
Assessing the influence of walnut consumption on fecal moisture.
Assessing the influence of walnut consumption on fecal pH.
Assessing the influence of walnut consumption on plasma and urine levels of walnut-derived metabolites - urolithins.
+2 moreOther study objectives
Anthropometric measurements
Food record analysis
Measure of changes in weight
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Active Control
Group I: No-nut dietActive Control1 Intervention
Participants will follow a no-nut diet for 3 weeks.
Group II: Walnut dietActive Control1 Intervention
Participants will consume 56 g of walnuts each day at home for 3 weeks.
Find a Location
Who is running the clinical trial?
University of California, DavisLead Sponsor
945 Previous Clinical Trials
4,756,110 Total Patients Enrolled