Theta Burst Stimulation for Depression
(ACT-LLD Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Centre for Addiction and Mental Health

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where participants receive a single TBS treatment daily) in late life depression. In addition, the study also aims to determine if specific patterns of stimulation are more or less effective. To do this, all participants will receive active treatments, but some of the participants in this study will receive accelerated TBS and some will receive once daily TBS.

Eligibility Criteria

This trial is for older adults with late-life depression. Participants should be experiencing depressive symptoms but the specific inclusion and exclusion criteria are not provided in the details given.

Inclusion Criteria

I am willing and able to agree to treatment.

Able to adhere to treatment schedule

PHQ-9 score ≥ 10

+6 more

Exclusion Criteria

Diagnosis of substance dependence or abuse within the last 3 months

Lifetime diagnosis of bipolar I or II disorder, or primary psychotic disorder

Concomitant major unstable medical illness

+13 more

Participant Groups

The study tests two different TBS (Theta Burst Stimulation) protocols: an accelerated version with multiple daily treatments versus a conventional approach with one treatment per day, to see which is more effective for depression.

2Treatment groups

Active Control

Group I: Accelerated TBSActive Control1 Intervention

Multiple treatments a day (5 treatments/day) for 4 consecutive days in the first week and 2 non-consecutive days in the second week.

Group II: Conventional TBSActive Control1 Intervention

Treatment once a day for 30 days (e.g., 5 days a week for 6 weeks)