Accelerated iTBS for Postpartum Depression

Age: 18 - 65

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Medical University of South Carolina

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

This trial tests a new magnetic pulse therapy for women with post-partum depression. The therapy aims to improve mood by stimulating a specific brain area. Researchers are comparing two different treatment schedules to see which is more effective and easier for patients to complete. This therapy has been used for major depression and postpartum depression.

Research Team

Eligibility Criteria

This trial is for women over 18 with postpartum depression, which started during the last trimester or within four weeks after giving birth. They must have a certain level of depression severity and be able to consent. Women can't join if they're pregnant, have substance use disorders (except tobacco), had pre-eclampsia/eclampsia, contraindications to rTMS like metal in the head or seizures, unstable medical conditions, recent suicidal behavior, psychosis, or cognitive impairments.

Inclusion Criteria

My depression started in the third trimester or within four weeks after giving birth.

Participants must have a HRSD17 >13 at baseline.

I am over 18 years old.

Exclusion Criteria

Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.

Participants must not have had pre-eclampsia or eclampsia during pregnancy.

You do not have a history of memory or thinking problems.

Treatment Details

Interventions

• iTBS (Transcranial Magnetic Stimulation)

Trial Overview The study tests an accelerated form of transcranial magnetic stimulation called iTBS on the left dorsolateral prefrontal cortex. It's given 10 times per day for six days to see if it's feasible and tolerable as a treatment for postpartum depression and how well it reduces depressive symptoms.

Participant Groups

Group I: iTBS Experimental Treatment 1 Intervention

accelerated iTBS to Left DLPFC

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials

994

Recruited

7,408,000+

Dr. Erik Summers

Medical University of South Carolina

Chief Medical Officer

MD from University of Alabama at Birmingham

Dr. Patrick J. Cawley

Medical University of South Carolina

Chief Executive Officer

MD, MBA