Computer-Based Intervention for Depression
Trial Summary
Yes, if you are part of the MDD sample, you must stop taking psychotropic medications for at least 2 weeks (6 weeks for fluoxetine, 6 months for neuroleptics, 2 weeks for benzodiazepines, and 2 weeks for any other antidepressants) before joining the trial.
Research shows that computer-assisted cognitive-behavior therapy (CBT) for depression can be as effective as traditional therapy. Programs like Good Days Ahead and MoodGYM have shown promising results, suggesting that computer-based interventions can help manage depression.
12345Research on computer-based treatments for depression suggests they are generally safe, with only a small percentage of participants experiencing any significant worsening of symptoms. These treatments are often compared to traditional therapy and have shown similar safety profiles.
13467Computer Task Manipulation is unique because it uses computer technology to deliver therapy, which can be a substitute or addition to traditional face-to-face therapy. This approach allows for remote access and flexibility, making it more accessible for people who may not be able to attend in-person sessions.
12348Eligibility Criteria
This trial is for female adolescents aged 14-18 with major depressive disorder, not on psychotropic meds for at least 2 weeks, and no first-degree relatives with depression or bipolar. They must be right-handed, English-speaking, in the follicular phase of their menstrual cycle for fMRI scanning, and have a personal cell-phone.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Initial Assessment
Clinical diagnostic interview and completion of questionnaires and assessments
fMRI and Surveys
Participants undergo an fMRI brain scan and complete surveys on their cell phone in the following week
3-Month Follow-up
Diagnostic interview, assessments, and questionnaires completed three months after the fMRI scan, with additional surveys on cell phone
6-Month Follow-up
Diagnostic interview, assessments, and questionnaires completed six months after the fMRI scan, with additional surveys on cell phone