Bleach Bath Treatment of Adults With Atopic Dermatitis
Trial Summary
What is the purpose of this trial?
This is pilot, mechanistic study to address whether bleach baths given to adult subjects with atopic dermatitis or eczema, who are colonized with the bacteria Staphylococcus aureus, will significantly alter their skin microbiome and in so doing improve their skin barrier, diminish expression of inflammatory proteins in the skin and improve itch. To answer these questions the investigators will perform a 3-month, pilot, investigator-initiated, single-center, open-label clinical study. This study will allow us to test the following hypothesis: 1) that bleach baths will normalize skin barrier function, 2) that bleach baths will diminish the local inflammatory response in the skin, and 3) that bleach baths will improve validated measures of itch (also called pruritus).
Research Team
Lisa Beck, MD
Principal Investigator
Department of Dermatology University of Rochester
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- Bleach Bath (Sodium Hypochlorite) (Anti-microbial)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Rochester
Lead Sponsor
Kevin Koch
University of Rochester
Chief Executive Officer since 2020
PhD in Organic Chemistry from the University of Rochester
Brian Druker
University of Rochester
Chief Medical Officer since 2015
MD from Harvard Medical School
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
Dr. Lindsey A. Criswell
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Director since 2021
MD, MPH, DSc
Dr. Robert Colbert
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Clinical Director since 2014
MD
National Eczema Association
Collaborator