Timing of Resistance Exercise for Insulin Sensitivity

Overseen By Tanya M Halliday, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: University of Utah

No Placebo Group

Trial Summary

What is the purpose of this trial?

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Eligibility Criteria

This trial is for men and women aged 50-74 with a BMI of at least 25 but less than 45, who are generally healthy but not very active. They shouldn't have major health issues like uncontrolled heart or lung diseases, recent cancer treatment, untreated thyroid problems, or a history of eating disorders or weight loss surgery.

Inclusion Criteria

I am 50-74 years old, overweight but not obese, with stable weight and not very active.

Exclusion Criteria

I have received cancer treatment within the last 5 years.

HbA1c >6.5%

Current or recent history (past 2 years) of eating disorder

Treatment Details

Interventions

• Resistance Exercise Timing (Behavioral Intervention)

Trial Overview The study is testing if doing resistance exercises in the morning (AM) versus evening (PM) affects insulin sensitivity and sleep differently. Participants will do workouts once in the AM and once in the PM on separate days with weeks apart to see which timing might help reduce Type 2 Diabetes risk more effectively.

Participant Groups

Group I: PM Resistance Exercise Experimental Treatment 1 Intervention

Resistance Exercise intervention taking place in the PM

Group II: AM Resistance Exercise Experimental Treatment 1 Intervention

Resistance Exercise intervention taking place in the AM

Who Is Running the Clinical Trial?

University of Utah

Lead Sponsor

Trials

1,169

Recruited

1,623,000+