Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Trial Summary
What is the purpose of this trial?
Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign antigens, they migrate to secondary lymphoid organs, where the processed antigens are presented to T cells. Various DC subsets with unique cell lineages, surface protein markers, and tissue localization determinants have been identified. For example, Langerhans cells (LCs) and interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the skin. Though both are expressed in the skin, they differ with respect to their origin and surface protein content and can activate distinct types of immune responses. They may also have different specificities for the capture of antigens and presentation to circulating T cells. To date, it is unknown what role, if any, the different DC populations that reside or repopulate in the skin play in the development and progression of skin graft-versus-host disease (GVHD) following bone marrow transplant.
Research Team
Eynav Klechevsky, Ph.D.
Principal Investigator
Washington University School of Medicine
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- Dendritic Cells (Cell Therapy)
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Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor
David H. Perlmutter
Washington University School of Medicine
Chief Executive Officer since 2015
MD from Washington University School of Medicine
Paul Scheel
Washington University School of Medicine
Chief Medical Officer since 2022
MD from Washington University School of Medicine