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Prebiotic

Inulin for Healthy Subjects

N/A
Recruiting
Led By Stephen Lindemann, PhD
Research Sponsored by Purdue University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adults aged 18-45
Be between 18 and 65 years old
Must not have
Self-reported antibiotic treatment in the past 6 months
Self-reported to having undergone major surgery of the gastrointestinal tract, with the exception of cholecystectomy and appendectomy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 days over 13 weeks

Summary

This trial aims to study how the gut microbiota in healthy adults responds to native chicory inulin. The researchers will also look at how chicory inulin affects bowel habits, mood, and appetite

Who is the study for?
This trial is for healthy adults interested in how a natural fiber, native chicory inulin, affects their gut bacteria compared to maltodextrin, a placebo. Participants will take supplements for 6 weeks and track changes in digestion, mood, and appetite.
What is being tested?
The study tests the impact of chicory inulin on gut microbiota against maltodextrin. It measures how quickly and persistently the gut bacteria change with daily supplementation over six weeks and observes these effects after stopping the supplement.
What are the potential side effects?
Possible side effects may include changes in gastrointestinal sensations such as bloating or discomfort due to increased fiber intake from chicory inulin. Mood alterations and variations in bowel habits or appetite might also be observed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 45 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have taken antibiotics in the last 6 months.
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I have had major surgery on my digestive system, except for gallbladder or appendix removal.
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I am currently pregnant or breastfeeding.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 days over 13 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 days over 13 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in Bifidobacterium counts in stool samples
Secondary study objectives
Appetite - Desire to eat something fatty
Appetite - Desire to eat something salty
Appetite - Desire to eat something sweet
+18 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Pure InulinExperimental Treatment1 Intervention
12 g/day prebiotic supplement
Group II: PlaceboPlacebo Group1 Intervention
6 g/day maltodextrin

Find a Location

Who is running the clinical trial?

Purdue UniversityLead Sponsor
233 Previous Clinical Trials
71,321 Total Patients Enrolled
Stephen Lindemann, PhDPrincipal InvestigatorPurdue University
~35 spots leftby Jul 2026
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