Exercise Programs for Knee Arthritis (CaRE Trial)
Recruiting in Palo Alto (17 mi)
Overseen BySara Piva
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Pittsburgh
No Placebo Group
Trial Summary
What is the purpose of this trial?This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.
How does the 'Exercise without Rest, Exercise with Rest' treatment for knee arthritis differ from other treatments?
This treatment is unique because it focuses on specific exercise regimens, either continuous or with rest periods, to manage knee arthritis, unlike traditional treatments that may rely more on medication or surgery. It emphasizes strengthening exercises, particularly for the quadriceps, which can help improve pain and function in the knee.
12678Is exercise safe for people with knee arthritis?
Exercise is generally safe for people with knee arthritis, with few side effects or risks. It is recommended as a first-line treatment and can help reduce pain and improve function.
3451012What data supports the effectiveness of the treatment Exercise without Rest, Exercise with Rest for knee arthritis?
Research shows that exercise programs, including home-based exercises and therapeutic exercises, are effective in reducing pain and improving function in people with knee arthritis. Different types of exercises, such as strengthening and aerobic exercises, can be beneficial when done at appropriate levels.
49111213Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you have a history of cardiovascular disease or hypertension, it must be controlled by medication to participate.
Eligibility Criteria
This trial is for people with knee osteoarthritis. It's designed to see if they can participate in two different exercise programs—one with rest breaks and one without. Specific eligibility details are not provided, so general health status may be considered.Inclusion Criteria
I am between 45 and 79 years old.
I have been diagnosed with early to moderate knee osteoarthritis.
Exclusion Criteria
I use a cane, walker, or crutches to walk.
I have severe knee arthritis.
I have had a knee injection in the last 3 months.
I have fallen unexpectedly at least twice in the last year.
My knee condition is not caused by osteoarthritis.
I have had major knee surgery or trauma in the last 5 years, or have hardware in my knee.
I have heart disease or high blood pressure not managed by medication.
I have a condition that affects my ability to walk or exercise.
Participant Groups
The study compares the feasibility of two exercise regimens for those with knee arthritis: a standard program versus one that includes rest periods. Participants will be randomly assigned to either group to evaluate which method works best.
2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise With RestExperimental Treatment1 Intervention
Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include two 45 minute rest periods between exercises and take about two and a half hours.
Group II: Exercise Without RestActive Control1 Intervention
Exercise without Rest
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
University of PittsburghPittsburgh, PA
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Who is running the clinical trial?
University of PittsburghLead Sponsor
Carnegie Mellon UniversityCollaborator
References
Feasibility of using quadriceps-strengthening exercise to improve pain and sleep in a severely demented elder with osteoarthritis - a case report. [2020]BACKGROUND: Osteoarthritis (OA) of the knee, which is prevalent among older adults in nursing homes, causes significant pain and suffering, including disturbance of nocturnal sleep. One nonpharmacologic treatment option is quadriceps-strengthening exercise, however, the feasibility of such a treatment for reducing pain from OA in severely demented elders has not been studied. This report describes our test of the feasibility of such an exercise program, together with its effects on pain and sleep, in a severely demented nursing home resident. CASE PRESENTATION: The subject was an elderly man with severe cognitive impairment (Mini-Mental Status Exam score 4) and knee OA (Kellgren-Lawrence radiographic grade 4). He was enrolled in a 5-week, 10-session standardized progressive-resistance training program to strengthen the quadriceps, and completed all sessions. Pain was assessed with the Western Ontario and MacMaster OA Index (WOMAC) pain subscale, and sleep was assessed by actigraphy.The patient was able to perform the exercises, with a revision to the protocol. However, the WOMAC OA pain subscale proved inadequate for measuring pain in a patient with low cognitive functioning, and therefore the effects on pain were inconclusive. Although his sleep improved after the intervention, the influence of his medications and the amount of daytime sleep on his nighttime sleep need to be considered. CONCLUSIONS: A quadriceps-strengthening exercise program for treating OA of the knee is feasible in severely demented elders, although a better outcome measure is needed for pain.
Vastus medialis activation during knee extension exercises: evidence for exercise prescription. [2022]Knee extension exercise is an important part of knee rehabilitation. Clinicians prescribe non-weight bearing exercise initially and progress patients to weight bearing exercise once they can perform a straight leg raise (SLR).
Diet and exercise for obese adults with knee osteoarthritis. [2022]Osteoarthritis (OA) is a common chronic disease and there is a need for treatments that can be provided for the course of the disease with minimal adverse side effects. Exercise is a safe intervention in patients with knee OA with few contraindications or adverse events. Obesity is the most modifiable risk factor for knee OA. The mechanisms by which obesity affects OA are of great concern to researchers and clinicians who manage this disease. This article reviews the physiologic and mechanical consequences of obesity and exercise on older adults with knee OA, the effects of long-term weight loss and exercise interventions, and the utility and feasibility of translating these results to clinical practice.
Exercise: necessary but not sufficient for improving function and preventing disability? [2011]Several recent clinical trials and systematic reviews have examined functional outcomes of exercise programs in two populations: older adults and adults with knee arthritis. We synthesize recent clinical trials and systematic reviews to examine whether the links between exercise and functional outcomes are better understood than they were a decade ago.
Managing Hip and Knee Osteoarthritis with Exercise: What is the Best Prescription? [2021]Hip and knee osteoarthritis are common, chronic, and disabling. Therapeutic exercise is a component of all major rheumatologic society guidelines, yet the frequency, dose, duration, and therapeutic threshold for exercise are not clearly delineated. This review summarizes current studies of exercise for hip and knee osteoarthritis, discusses issues that influence the design, interpretation, and aggregation of results and how these factors impact the translation of data into clinical practice. A review of databases to identify current randomized controlled trials (2000 to present) of exercise to manage the symptoms of hip and knee osteoarthritis is discussed here. One study enrolling only hip patients was identified. Six studies of outcomes for individuals with hip or knee osteoarthritis and 11 studies of persons with knee osteoarthritis were found. Limited studies focus specifically on exercise for persons with hip osteoarthritis. Exercise is provided as a complex intervention combining multiple modes and provided in various settings under a range of conditions. Regardless of the variability in results and inherent biases in trials, exercise appears to reduce pain and improve function for persons with knee osteoarthritis and provide pain relief for persons with hip osteoarthritis. Given the complexity of exercise interventions and the specific issues related to study design, novel approaches to the evaluation of exercise are warranted.
King vs Arthritis: Advantage, King. [2016]As a pro, Billie Jean King used a vigorous exercise program to help control arthritis in her knees. The results speak for themselves.
The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. [2022]To identify effective mind-body exercise programs and provide clinicians and patients with updated, high-quality recommendations concerning non-traditional land-based exercises for knee osteoarthritis.
The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. [2022]To identify effective strengthening exercise programs and provide rehabilitation teams and patients with updated, high-quality recommendations concerning traditional land-based exercises for knee osteoarthritis.
Comparison of effectiveness of the home exercise program and the home exercise program taught by physiotherapist in knee osteoarthritis. [2019]Home-based exercise therapy is effective in reducing pain and improving function in adults with osteoarthritis of the knee.
Effect of Body Weight-Supported Exercise on Symptoms of Knee Osteoarthritis: A Follow-up Investigation. [2021]To examine the long-term effect of participation in a 12-week lower-body positive pressure (LBPP)-supported low-load treadmill exercise regime on knee joint pain, physical function, and thigh muscle strength in patients with knee osteoarthritis (OA).
Long term efficacy of mobilisation with movement on pain and functional status in patients with knee osteoarthritis: a randomised clinical trial. [2022]To evaluate the long term effect of mobilisation with movement on disability, pain and function in subjects with symptomatic knee osteoarthritis.
Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us? [2022]Therapeutic exercise is a recommended first-line treatment for patients with knee and hip osteoarthritis (OA); however, there is little specific advice or practical resources to guide clinicians in its implementation. As the first in a series of projects by the Osteoarthritis Research Society International Rehabilitation Discussion Group to address this gap, we aim in this narrative review to synthesize current literature informing the implementation of therapeutic exercise for patients with knee and hip OA, focusing on evidence from systematic reviews and randomized controlled trials. Therapeutic exercise is safe for patients with knee and hip OA. Numerous types of therapeutic exercise (including aerobic, strengthening, neuromuscular, mind-body exercise) may be utilized at varying doses and in different settings to improve pain and function. Benefits from therapeutic exercise appear greater when dosage recommendations from general exercise guidelines for healthy adults are met. However, interim therapeutic exercise goals may also be useful, given that many barriers to achieving these dosages exist among this patient group. Theoretically-informed strategies to improve adherence to therapeutic exercise, such as patient education, goal-setting, monitoring, and feedback, may help maintain participation and optimize clinical benefits over the longer term. Sedentary behavior is also a risk factor for disability and lower quality of life in patients with knee and hip OA, although limited evidence exists regarding how best to reduce this behavior. Current evidence can be used to inform how to implement best practice therapeutic exercise at a sufficient and appropriate dose for patients with knee and hip OA.
Sensory-motor training versus resistance training in the treatment of knee osteoarthritis: A randomized controlled trial. [2023]To compare the effectiveness of sensory-motor training and resistance training in patients with knee osteoarthritis.