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Mineral Supplement

Magnesium Supplementation for Heart Surgery Complications

N/A
Waitlist Available
Led By David A Rosen, MD
Research Sponsored by West Virginia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Children undergoing cardiac surgery utilizing cardiopulmonary bypass
Be younger than 65 years old
Must not have
Children with Renal disease
Children undergoing cardiac surgery without cardiopulmonary bypass
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours after reanimation
Awards & highlights

Summary

This trial aims to find the best way to measure blood magnesium levels in children after heart surgery. By measuring both active and total magnesium separately, doctors hope to better personalize the dose of a magnesium supplement called

Who is the study for?
This trial is for children undergoing heart surgery who may face post-surgery complications like heart and kidney issues. It aims to personalize magnesium supplementation (MgSO4) based on blood levels to improve outcomes.
What is being tested?
The study tests two methods of measuring magnesium in the blood: ionized (active) and total magnesium, to determine which is better for guiding MgSO4 dosing after pediatric heart surgery.
What are the potential side effects?
While not explicitly stated, potential side effects might include imbalances in electrolytes due to incorrect MgSO4 dosing, which could affect heart rhythm and kidney function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My child is having heart surgery with a heart-lung machine.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My child has kidney disease.
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My child is having heart surgery without using a heart-lung machine.
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My child has a heart rhythm problem.
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My child is on medication for irregular heartbeats.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours after reanimation
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours after reanimation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Presence of any arrhythmia
Urine Creatinine concentration
Urine NGAL concentration

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Total magnesiumExperimental Treatment1 Intervention
Magnesium dosing based on total Mg blood level
Group II: ionized MagnesiumActive Control1 Intervention
Magnesium dosing based upon ionized Mg level

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Who is running the clinical trial?

West Virginia UniversityLead Sponsor
181 Previous Clinical Trials
63,615 Total Patients Enrolled
David A Rosen, MDPrincipal InvestigatorWest Virginia University
1 Previous Clinical Trials
59 Total Patients Enrolled
~64 spots leftby Dec 2026
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