Predictive Analytics + Clinical Decision Support for HIV Prevention

(PrEDICT Trial)

Recruiting at 15 trial locations

Overseen By Julia Marcus, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Harvard Pilgrim Health Care

No Placebo Group

Trial Summary

What is the purpose of this trial?

Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the U.S. initiative to end the HIV epidemic, but healthcare providers lack tools to support PrEP discussions and prescribing for patients likely to benefit. This research will evaluate whether integrating automated tools into electronic health records to help providers efficiently and equitably identify potential candidates for PrEP, discuss PrEP, and prescribe PrEP can improve PrEP initiation and persistence in safety-net community health centers. It will achieve this by conducting a stepped-wedge trial of a decision support tool with an embedded HIV prediction model to identify patients likely to benefit from PrEP. The intervention will be delivered to healthcare providers in 16 community health centers within the national OCHIN network.

Eligibility Criteria

This trial is for healthcare providers at community health centers that saw over 500 patients in 2024, had at least 10 new HIV diagnoses in 2023, and offer primary care services (excluding pediatrics) active on OCHIN Epic since January 1, 2023.

Inclusion Criteria

My healthcare facility reported at least 10 new HIV cases in 2023.

My primary care provider is active on OCHIN Epic since 1/1/2023 and does not specialize in pediatrics.

My healthcare provider had over 500 patients in 2024.

Treatment Details

Interventions

• Predictive Analytics and Clinical Decision Support (Behavioural Intervention)

Trial Overview The study tests a decision support tool integrated into electronic health records. It uses predictive analytics to help providers identify who might benefit from HIV PrEP, discuss it with them, and prescribe it more effectively and equitably.

Participant Groups

Group I: Standard of Care Active Control 1 Intervention

Data will be extracted from EHRs of control clinics as a comparison, and those clinics will not actively participate in study activities

Group II: Predictive analytics and clinical decision support Active Control 1 Intervention

Providers in enrolled intervention clinics will receive point-of-care notifications via the EHR-embedded decision support tool about patients who are at increased predicted HIV risk and therefore likely to benefit from PrEP

Who Is Running the Clinical Trial?

Harvard Pilgrim Health Care

Lead Sponsor

Trials

61

Recruited

27,990,000+

Oregon Health and Science University

Collaborator

Trials

1,024

Recruited

7,420,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials

3,007

Recruited

2,852,000+

Oregon Health & Science University (OHSU)

Collaborator

Trials

1

Recruited

20+

OCHIN, Inc.

Collaborator

Trials

24

Recruited

9,964,000+