← Back to Search

MR Evaluation for Brain Health

N/A

Recruiting

Led By Petrice Cogswell, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination.

Be older than 18 years old

Must not have

Subjects requiring sedation

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at the time of mr exam, approximately one hour

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a new way to detect Cerebral Spinal Fluid (CSF) flow in the brain to help with diagnosis and understanding of diseases that affect brain function.

Who is the study for?

This trial is for healthy individuals and those with suspected altered CSF dynamics, such as hydrocephalus or cognitive impairments like Alzheimer's. Participants should not have conditions affecting brain function or memory issues. Pregnant women, people needing sedation for MRI, or those with non-MRI compatible devices cannot join.

What is being tested?

The study is testing a new MR imaging method to observe the flow of cerebrospinal fluid (CSF) in the brain. This could improve diagnosis and understanding of conditions like Alzheimer's Disease and Hydrocephalus that impact brain function.

What are the potential side effects?

As this trial involves standard MRI procedures, side effects are minimal but may include discomfort from lying still during the scan or reactions to contrast agents if used—like mild pain, coldness at the injection site, or light-headedness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am healthy with no brain function issues or problems with concentration, memory, balance, or coordination.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I need medication to help me stay calm or asleep.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at the time of mr exam, approximately one hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at the time of mr exam, approximately one hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and at the time of mr exam, approximately one hour for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

CSF flow measurement

Secondary study objectives

Volume of CSF spaces

White matter disease

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: MR brainExperimental Treatment3 Interventions

Participants will be asked to complete a MRI screening form to check for the presence of metallic implants and materials. People with pacemakers, aneurysm clips, and cochlear implants, or metal/foreign objects in their eyes cannot have an MRI and will not be able to participate in the study. Pre-menopausal females will be asked if they think they may be pregnant. If yes, a urine pregnancy test will be performed. Those who meet eligibility criteria for the study and have agreed to participate will be taken to the MRI suite when MR imaging of the brain will be performed.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Urine pregnancy test

2006

Completed Phase 3

~120

0 / 2Eligibility criteria met