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Behavioral Intervention

Rumination-Focused Cognitive Behavioral Therapy for Depression (RFCBT-I Trial)

N/A
Recruiting
Led By Patrick Possel, Dr.rer.soc.
Research Sponsored by University of Louisville
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 33 weeks after baseline 1
Awards & highlights
No Placebo-Only Group

Summary

This trial will explore if treating depression can reduce risk of heart disease in low-income Americans. #HeartDisease #Depression #RFCBT

Who is the study for?
This trial is for individuals who often have negative thoughts that loop continuously (rumination), are experiencing mild to moderate depression, and have high blood pressure. Participants must score at least 11 on the RSQ-Brooding scale, between 10-20 on the PHQ-9 depression scale, and have a systolic blood pressure of 120 or higher or diastolic blood pressure of 80 or higher. They also need to be fluent in English.
What is being tested?
The study is testing Rumination-Focused Cognitive Behavioral Therapy (RFCBT) to see if it can reduce the risk of heart disease by targeting rumination—a factor linked to both depression and heart health—especially in low-income patients.
What are the potential side effects?
Since RFCBT is a type of talk therapy focused on changing thought patterns, there are no direct physical side effects like with medication. However, discussing negative thoughts may initially cause discomfort or emotional distress.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~33 weeks after baseline 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and 33 weeks after baseline 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Patient Health Questionnaire-9
Response Style Questionnaire
diastolic blood pressure measures
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: RFCBTExperimental Treatment1 Intervention
This is a single subject design study. Thus, all participants receive Rumination-Focused Cognitive Behavior Therapy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rumination-Focused Cognitive Behavior Therapy
2013
N/A
~40

Find a Location

Who is running the clinical trial?

University of LouisvilleLead Sponsor
347 Previous Clinical Trials
77,592 Total Patients Enrolled
Patrick Possel, Dr.rer.soc.Principal InvestigatorUniversity of Louisville
1 Previous Clinical Trials
740 Total Patients Enrolled
~5 spots leftby Aug 2026
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