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Mango for Prediabetes

N/A

Recruiting

Led By Celine Heskey, DrPH

Research Sponsored by Loma Linda University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Abdominal obesity as defined as a waist circumference >102 cm for men or >88 cm for women

Be between 18 and 65 years old

Must not have

Not able to read and/or communicate in English

Timeline

Screening 3 weeks

Treatment Varies

Follow Up fasting blood glucose and insulin will be measured in fasting blood that will be drawn at weeks 0 and 12 of the first phase and the last week of the second phase of the study.

Awards & highlights

No Placebo-Only Group

Summary

This trial tests the effect of eating 1.5 cups of mango per day for 12 weeks on indicators of glycemia, insulin resistance, lipids, inflammation, oxidation and body composition in people with prediabetes.

Who is the study for?

This trial is for individuals with prediabetes, indicated by HgbA1c levels of 5.7 to 6.4%, and abdominal obesity (waist >102 cm for men, >88 cm for women). Excluded are those with chronic diseases, pacemakers, mango or latex allergies, smokers, high alcohol consumers (>2 drinks/day for men or >1 drink/day for women), recent significant weight loss (>5% in past 6 months), BMI over 35 kg/m^2, pregnant or breastfeeding women, on certain medications/supplements affecting blood sugar/lipids or who regularly consume lots of mangos/fruits.

What is being tested?

The study tests if eating 1.5 cups of fresh mango daily over a period of 12 weeks can improve glucose control and insulin resistance in people with prediabetes. It also looks at the effects on cholesterol levels (LDL/HDL/total/triglycerides), oxidative stress markers like oxidized LDL-cholesterol and inflammation indicators such as c-reactive protein. Participants will alternate between consuming mangos and not consuming them to compare changes.

What are the potential side effects?

Potential side effects from consuming mangos may include digestive issues like bloating or gas due to increased fiber intake; however specific side effects related to this intervention have not been detailed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My waist is over 102 cm if I am a man, or over 88 cm if I am a woman.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I cannot read or communicate in English.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ fasting blood glucose and insulin will be measured in fasting blood that will be drawn at weeks 0 and 12 of the first phase and the last week of the second phase of the study.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~fasting blood glucose and insulin will be measured in fasting blood that will be drawn at weeks 0 and 12 of the first phase and the last week of the second phase of the study.

This trial's timeline: 3 weeks for screening, Varies for treatment, and fasting blood glucose and insulin will be measured in fasting blood that will be drawn at weeks 0 and 12 of the first phase and the last week of the second phase of the study. for reporting.