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Forced Desynchrony for High Blood Pressure

N/A
Recruiting
Led By Steven A Shea, PhD
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Free of all prescription and non-prescription drugs (including caffeine, nicotine, alcohol and herbal medications)
Be between 18 and 65 years old
Must not have
Moderate to severe obstructive sleep apnea (OSA)
Currently treated with pharmacologic agents for hypertension
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7-day lab stay
Awards & highlights
No Placebo-Only Group

Summary

This trial will help determine if different therapies for hypertension are effective for black adults based on the root cause of their hypertension.

Who is the study for?
This trial is for self-identified Black or White adults who are either 'normotensive' with blood pressure under 140/90 mmHg, or have stage 1 hypertension with systolic BP between 140 and 160 mmHg or diastolic BP between 90 and 100 mmHg. Participants should not be on any medication (including caffeine and alcohol), must not smoke, do night shifts, or have traveled across time zones recently. They also shouldn't have severe health issues like renal disease.
What is being tested?
The study investigates how sleep, circadian rhythms, and behaviors contribute to non-dipping blood pressure profiles in Black adults compared to White adults. It aims to understand if race influences the best treatment for hypertension by examining these different factors.
What are the potential side effects?
Since this trial involves behavioral interventions rather than medications, there may be minimal side effects related directly to the intervention itself. However, changes in sleep patterns could potentially cause temporary fatigue or stress.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am not taking any prescription, over-the-counter drugs, or substances like caffeine or alcohol.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have been diagnosed with moderate to severe sleep apnea.
Select...
I am taking medication for high blood pressure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7-day lab stay
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7-day lab stay for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Blood pressure
Heart rate variability
Secondary study objectives
24-hr ambulatory blood pressure
beat-by-beat blood pressure
flow mediated dilation
+6 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Forced DesynchronyExperimental Treatment1 Intervention
All participants will undergo a forced desynchrony protocol.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Forced Desynchrony
2014
N/A
~40

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
1,006 Previous Clinical Trials
7,413,867 Total Patients Enrolled
6 Trials studying Cardiovascular Risk
1,630 Patients Enrolled for Cardiovascular Risk
Steven A Shea, PhDPrincipal InvestigatorOre
3 Previous Clinical Trials
73 Total Patients Enrolled
1 Trials studying Cardiovascular Risk
16 Patients Enrolled for Cardiovascular Risk

Media Library

Forced Desynchrony Clinical Trial Eligibility Overview. Trial Name: NCT03558893 — N/A
Cardiovascular Risk Research Study Groups: Forced Desynchrony
Cardiovascular Risk Clinical Trial 2023: Forced Desynchrony Highlights & Side Effects. Trial Name: NCT03558893 — N/A
Forced Desynchrony 2023 Treatment Timeline for Medical Study. Trial Name: NCT03558893 — N/A
~1 spots leftby Dec 2024
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