Uterine Flushing for Unexplained Infertility

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: CHU de Quebec-Universite Laval

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing if washing the uterus with saltwater before ovulation can help women aged 18-37 who have unexplained infertility. The treatment might work by clearing out debris or changing inflammation in the uterus to make it easier to get pregnant.

Eligibility Criteria

This trial is for people with unexplained infertility who have tried to conceive for at least a year. They must have normal reproductive hormone levels, regular menstrual cycles, and no blockages in their fallopian tubes. Their partners should have normal semen analysis results, and they must not have any infections like gonorrhea or chlamydia.

Inclusion Criteria

Primary or secondary infertility ≥12 months

I meet all the fertility health criteria and have unexplained infertility for less than 2 years.

Exclusion Criteria

Body mass index ≥35 kg/m2

Ongoing pregnancy

Participant Groups

The study is testing if washing the inside of the uterus with saline solution before ovulation can help couples with unexplained infertility get pregnant. It involves timed sexual intercourse and monitoring ovulation closely.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Uterine flushingExperimental Treatment3 Interventions

Detection of ovulation, injection of 20 millilitres of physiological saline by an intra-uterine catheter the day of the luteinizing hormone surge, and sexual intercourse within 12 hours after intervention

Group II: Vaginal flushingPlacebo Group3 Interventions

Detection of ovulation, injection of 10 millilitres of physiological saline intravaginally the day of the luteinizing hormone surge, and sexual intercourse within 12 hours after intervention