Trial Summary
What is the purpose of this trial?
Over half of adults in this country are overweight. This increases risk for heart and blood pressure problems, cancer, stroke and arthritis. While it is difficult to lose large amounts of weight and keep it off, even small amounts of weight loss can improve health. Furthermore, fat is increasingly recognized as a source of substances that increase inflammation. It may be that some of the adverse consequences of being overweight are due to increased inflammation. We are asking you to volunteer for a research study in which you may lose a moderate amount of weight and increase your activity. It is important that you read and understand the information on this form. The purposes of these studies are to determine the influence(s) of age and body composition on the production of inflammatory chemicals by fat (adipose tissue), the mechanisms controlling this, and if a weight loss and aerobic exercise intervention results in a decrease in inflammation.
Eligibility Criteria
This study is for veterans who are overweight with a waist size of 80-120cm for men or 70-110cm for women, have a stable medical regimen, and BMI between 20-40. Women over 50 must be postmenopausal. Participants should not smoke, have certain chronic diseases, uncontrolled hypertension, recent significant weight changes, or use medications affecting metabolism.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Weight loss and aerobic exercise training (Behavioral Intervention)