Speech Sequencing Therapies for Stuttering
Trial Summary
What is the purpose of this trial?
Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life. Despite its prevalence and negative impact, stuttering has resisted explanation and effective treatment, due in large part to a poor understanding of the neural processing impairments underlying the disorder. The overall goal of this study is to improve understanding of the brain mechanisms involved in speech motor planning and how these are disrupted in neurogenic speech disorders, like stuttering. The investigators will do this through an integrated combination of experiments that involve speech production, functional MRI, and non-invasive brain stimulation. The study is designed to test hypotheses regarding the brain processes involved in learning and initiating new speech sound sequences and how those processes compare in persons with persistent developmental stuttering and those with typical speech development. These processes will be studied in both adults and children. Additionally, these processes will be investigated in patients with neurodegenerative speech disorders (primary progressive aphasia) to further inform the investigators understanding of the neural mechanisms that support speech motor sequence learning. Together these experiments will result in an improved account of the brain mechanisms underlying speech production in fluent speakers and individuals who stutter, thereby paving the way for the development of new therapies and technologies for addressing this disorder.
Do I need to stop my current medications to join the trial?
If you have primary progressive aphasia (PPA), you cannot participate if you are taking medications that affect speech or language. For others, the protocol does not specify if you need to stop taking your current medications.
What data supports the effectiveness of the treatment Speech Sequencing Therapies for Stuttering?
Research shows that fluency training, which is part of speech therapy for stuttering, significantly reduces stuttering frequency and improves speaking rate and communication attitudes. Additionally, modified stuttering therapy programs focusing on self-therapy and specific target responses have led to greater improvements in speech fluency.12345
How is the Speech Sequencing Therapy for Stuttering different from other treatments?
This treatment is unique because it focuses on practicing non-native phoneme combinations and multisyllabic nonwords, which helps improve speech fluency by enhancing the brain's ability to store and recall speech sequences as cohesive chunks, reducing memory load and improving motor performance.26789
Eligibility Criteria
This trial is for native American English speakers with limited second language exposure. It includes children who pass a hearing test, adults without neurological issues (except stuttering), and those diagnosed with primary progressive aphasia by MGH-FTD. Excluded are individuals with contraindications to MRI or tDCS, certain medication use in PPA patients, severe cognitive impairment, and outside the age range for child participants.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Training
Participants undergo training sessions to learn novel speech sequences using various methods such as tDCS and fMRI
Intervention
Functional MRI and other assessments are conducted to measure brain activity and speech performance
Follow-up
Participants are monitored for changes in speech performance and brain activity post-intervention
Treatment Details
Interventions
- Anodal tDCS (Device)
- Learning of non-native phoneme combinations: 1 training session (Behavioral Intervention)
- Learning of non-native phoneme combinations: 6 training sessions (Behavioral Intervention)
- Learning of non-native phoneme combinations: 8 training sessions (Behavioral Intervention)
- Learning of novel multisyllabic nonwords (Behavioral Intervention)
- Sham tDCS (Device)