The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
Trial Summary
What is the purpose of this trial?
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, there are different types of ketone supplements that differ in how they are metabolized in the body. Little is known about how these supplements affect blood ketone and blood glucose levels. The main objective of this study is to determine the effect of three different ketone supplements on blood ketones and blood glucose. The results of this pilot study will be used to guide future research for larger and more extensive studies on ketone supplements.
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- 1,3-Butanediol (Ketone Supplement)
- Beta-hydroxybutyric acid (Ketone Supplement)
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester (Ketone Supplement)
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Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor