Dietary Intervention for Polycystic Kidney Disease

(ADPKD Trial)

Overseen By Sayna Norouzi, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Loma Linda University

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this interventional study is to evaluate the impact of a specific diet (low salt, limited caffeine, high potassium, low phosphate, limited protein, limited carbohydrate intake, adequate water intake) on changes in serum and urinary biomarkers, total kidney volume (TKV), and cyst progression in subjects with autosomal dominant polycystic kidney disease (ADPKD). Researchers will compare the results of subjects in the study diet (interventional) arm to the results of subjects in the regular diet (control) arm.

Research Team

Amir Abdipour, MD

Principal Investigator

Loma Linda University Health

Eligibility Criteria

This trial is for people with autosomal dominant polycystic kidney disease (ADPKD). Participants should be willing to follow a specific diet plan. The exact eligibility criteria are not provided, but typically include factors like age range, stage of the disease, and overall health status.

Inclusion Criteria

I have been diagnosed with ADPKD.

Willingness to adhere to a preconditioning diet for 1 week and ability to complete the study

My kidney function is above the minimum level required.

Exclusion Criteria

I do not have severe diabetes, heart failure, or advanced kidney disease.

History of dietary non-adherence

I am currently taking Tolvaptan.

Treatment Details

Interventions

• Interventional Diet (Behavioural Intervention)

Trial Overview The study tests how a special diet affects ADPKD. This diet includes low salt, limited caffeine and protein, high potassium, low phosphate, controlled carbs, and proper water intake. Researchers will compare changes in biomarkers and kidney size between those on this diet versus a regular diet.

Participant Groups

Group I: Interventional Diet Experimental Treatment 1 Intervention

Subjects will follow a specified diet (low salt, limited caffeine, high potassium, low phosphate, and limited protein and carbohydrate intake along with adequate water intake) after 1 week of preconditioning for 12 months.

Group II: Regular Diet Active Control 1 Intervention

Subjects will follow the diet they normally adhere to after 1 week of preconditioning.

Who Is Running the Clinical Trial?

Loma Linda University

Lead Sponsor

Trials

322

Recruited

267,000+