Dietary Intervention for Polycystic Kidney Disease (ADPKD Trial)

Recruiting in Palo Alto (17 mi)

Overseen ByAmir Abdipour, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Loma Linda University

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this interventional study is to evaluate the impact of a specific diet (low salt, limited caffeine, high potassium, low phosphate, limited protein, limited carbohydrate intake, adequate water intake) on changes in serum and urinary biomarkers, total kidney volume (TKV), and cyst progression in subjects with autosomal dominant polycystic kidney disease (ADPKD). Researchers will compare the results of subjects in the study diet (interventional) arm to the results of subjects in the regular diet (control) arm.

Eligibility Criteria

This trial is for people with autosomal dominant polycystic kidney disease (ADPKD). Participants should be willing to follow a specific diet plan. The exact eligibility criteria are not provided, but typically include factors like age range, stage of the disease, and overall health status.

Inclusion Criteria

I have been diagnosed with ADPKD.

My kidney function is above the minimum level required.

My condition is confirmed by genetic testing for PKD1 or PKD2.

Exclusion Criteria

I am currently taking Tolvaptan.

Participant Groups

The study tests how a special diet affects ADPKD. This diet includes low salt, limited caffeine and protein, high potassium, low phosphate, controlled carbs, and proper water intake. Researchers will compare changes in biomarkers and kidney size between those on this diet versus a regular diet.

2Treatment groups

Experimental Treatment

Active Control

Group I: Interventional DietExperimental Treatment1 Intervention

Subjects will follow a specified diet (low salt, limited caffeine, high potassium, low phosphate, and limited protein and carbohydrate intake along with adequate water intake) after 1 week of preconditioning for 12 months.

Group II: Regular DietActive Control1 Intervention

Subjects will follow the diet they normally adhere to after 1 week of preconditioning.