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Behavioral Intervention

Noise Correlations Study for Dyslexia

N/A

Recruiting

Led By Matthew Nassar, PhD

Research Sponsored by Brown University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age above 18

Be older than 18 years old

Must not have

Eye diseases/impairment including cataracts, macular degeneration, retinopathies, partial vision loss

Neuroleptics medications

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through completion of analysis, an average of 6 months

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to study how the brain processes information using noisy neurons. The researchers believe that noise correlations between neurons may actually help reduce the complexity of learning tasks. They plan to test this hypothesis using computational

Who is the study for?

This trial is for individuals with dyslexia or tinnitus. Specific eligibility criteria are not provided, but typically participants would need to be in good health and able to perform the tasks required by the study.

What is being tested?

The study investigates how 'noise correlations' between neurons affect learning. Participants will undergo a dynamic perceptual discrimination task while their brain activity is monitored using fMRI and pupillometry techniques.

What are the potential side effects?

There are generally no direct side effects from participating in this type of cognitive neuroscience study. However, some individuals may experience discomfort from lying still during fMRI scanning or mild eye strain from pupillometry.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am over 18 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have an eye condition like cataracts or macular degeneration.

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I am taking medication for my mental health.

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I am under 18 years old.

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I have a history of stroke, brain injury, epilepsy, or severe mental health issues.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through completion of analysis, an average of 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through completion of analysis, an average of 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and through completion of analysis, an average of 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Noise correlations in the brain

Participant learning asymmetry in the behavioral task

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Dynamic perceptual discrimination taskExperimental Treatment2 Interventions

The task featured two task conditions, each of which required the integration of information from both stimulus dimensions. In each condition, participants viewed a stimulus containing motion and color information and were required to specify one of two possible responses. Within each condition, rules and the response mapping changed occasionally, but always by changing on a fixed feature dimension (ie. rightward/purple, leftward/orange). These uncued intra-dimensional shifts involved translational shifts in the learning boundary, requiring them to adapt their decision making within a familiar dimension. These shifts compelled participants to continuously adjust their learning strategies by focusing on the most relevant feature dimension.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

fMRI

2019

Completed Phase 3

~1730

0 / 5Eligibility criteria met