Imaging Techniques for Chronic Rejection
SF
SF
Overseen BySean Fain, Ph.D.
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1 & 2
Recruiting
Sponsor: Sean Fain
No Placebo Group
Trial Summary
What is the purpose of this trial?
This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.
Research Team
SF
Sean Fain, Ph.D
Principal Investigator
University of Iowa
Eligibility Criteria
This trial is for English-speaking adults aged 18-80 who have had a bilateral lung transplant at least 6 months ago. They must be non-smokers with stable lung function tests and no current lung infections or rejection. Participants need to have normal chest X-rays and be able to consent.Inclusion Criteria
I am between 18 and 80 years old.
I speak English.
My lung function tests are stable and above 90% of my best recorded values.
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Treatment Details
Trial OverviewThe study is testing the effectiveness of advanced MRI techniques (OE-MRI, hyperpolarized gas MRI) and contrast-enhanced CT scans in understanding Chronic Lung Allograft Dysfunction (CLAD) in patients who've undergone lung transplants.
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Group I: Post Lung Transplant with normal functioningExperimental Treatment4 Interventions
Subjects who have had a lung transplant and now have normal lung function
Group II: Post Lung Transplant with Chronic Lung Allograft Dysfunction (CLAD)Experimental Treatment4 Interventions
Subjects who have had a lung transplant that now have CLAD
Group III: Healthy Normal SubjectsActive Control4 Interventions
Healthy subjects, with no lung diagnosis, who are non-smokers.
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Who Is Running the Clinical Trial?
Sean Fain
Lead Sponsor
Trials
1
Recruited
100+