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Pulmonary Rehab for COPD and Lung Cancer (PREHAB Trial)

N/A
Recruiting
Research Sponsored by University of Vermont
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 years or older
Physician diagnosis of COPD
Must not have
Ineligible for surgical resection (including suspicion for metastatic disease) as determined by the study physician and/or LMDC treatment physicians
Inability to consistently attend PR over a 2-week period
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, approximately 2 years
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to study the impact of prehabilitation on individuals with COPD and lung nodules who are preparing for surgery to remove the nodules. Participants will be recruited from the University of Vermont

Who is the study for?
This trial is for individuals who are currently smoking, have been diagnosed with COPD (Chronic Obstructive Pulmonary Disease), and either confirmed or suspected lung cancer with plans for surgery. They must be patients at the University of Vermont Medical Center and willing to undergo prehabilitation and consider quitting smoking.
What is being tested?
The study tests a pulmonary rehabilitation program before surgery in smokers with COPD and lung nodules. It aims to see if this 'prehab' can improve fitness, respiratory symptoms, depression, reduce anxiety, change smoking habits, and decrease surgical complications.
What are the potential side effects?
Potential side effects from the pulmonary rehab may include muscle soreness or fatigue due to exercise. Smoking cessation therapy might cause mood swings, cravings or other withdrawal symptoms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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My doctor has diagnosed me with COPD.
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I am a candidate for surgery to remove my cancer.
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My lung cancer is at an early stage and I am planning to have surgery to remove part of my lung.
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I am willing to use nicotine replacement and varenicline.
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I can attend 16 sessions over 8 days in 2 weeks for pulmonary rehabilitation.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My cancer cannot be removed by surgery as determined by my doctors.
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I cannot commit to attending pulmonary rehabilitation consistently for 2 weeks.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, approximately 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, approximately 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Average Pulmonary Rehab sessions completed
Proportion of patients determined eligible who enroll in the study

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: PrehabExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of VermontLead Sponsor
278 Previous Clinical Trials
3,744,124 Total Patients Enrolled
~7 spots leftby Jun 2025
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