OFDI Imaging for Coronary Artery Disease

Recruiting in Palo Alto (17 mi)

+2 other locations

Overseen ByGuillermo Tearney, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?Atherosclerosis, a condition in which fatty deposits of plaque build up along the inner walls of arteries, is a condition that may increase the risk of having a heart attack. Previous studies have shown that the presence of a specific kind of plaque, known as vulnerable plaque, is often found in people who have had a heart attack. This study will use a new imaging technique called optical frequency domain imaging (OFDI) to examine the presence of vulnerable plaques in people with coronary artery disease.

Eligibility Criteria

This trial is for people with coronary artery disease who are undergoing a procedure called PCTI. Women of childbearing age must test negative for pregnancy before joining. People can't join if they have kidney issues, recent heart attacks, complex heart lesions, severe vascular disease, congestive heart failure, previous bypass surgery or are in another study.

Inclusion Criteria

I am receiving treatment for blocked heart arteries.

I am a woman who can have children and I have a negative pregnancy test from the last week.

Exclusion Criteria

I have a condition affecting the main artery of my heart.

I have had heart bypass surgery.

My kidney function is reduced.

+10 more

Participant Groups

The trial is testing a new imaging method called OFDI to spot vulnerable plaques in the arteries that could lead to heart attacks. It aims to see how well this technique works in identifying these risky plaques compared to current methods.

2Treatment groups

Experimental Treatment

Group I: OFDI imagingExperimental Treatment1 Intervention

OFDI catheter advanced to the distal coronary artery

Group II: Intravenous UltrasoundExperimental Treatment1 Intervention

Randomization to determine whether Intravenous Ultrasound will be conducted before or after OFDI imaging.