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Photoacoustic Imaging for Lymph Node Cancer
Phase < 1
Waitlist Available
Led By Priya R Bhosale
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Scheduled to undergo ultrasound-guided fine needle aspiration cytology or biopsy
Pathologically proven primary malignancy
Must not have
The deeper inguinal lymph nodes (3-5 cm deep) and smaller (< 1 cm in short axis) in dimensions will be excluded from the study
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 months
Awards & highlights
No Placebo-Only Group
Summary
This trial uses ultrasound & light to detect cancer in groin lymph nodes, which may help prevent unnecessary surgery.
Who is the study for?
This trial is for cancer patients with suspicious groin lymph nodes identified by standard imaging and scheduled for needle aspiration or biopsy. It's not suitable for melanoma patients or those with deep (3-5 cm) or small (<1 cm) lymph nodes.
What is being tested?
The study tests ultrasound-guided photoacoustic imaging to distinguish between healthy and cancerous groin lymph nodes, aiming to improve tumor staging and reduce unnecessary surgeries.
What are the potential side effects?
As a non-invasive imaging technique, ultrasound-guided photoacoustic imaging has minimal side effects, primarily related to the discomfort from the ultrasound procedure itself.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am scheduled for a needle biopsy guided by ultrasound.
Select...
My cancer diagnosis was confirmed through a biopsy.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
My lymph nodes are not deep (3-5 cm) or small (<1 cm) enough to be excluded.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 3 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Difference between background oxygen saturation (%sO2) and nodal %sO2
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Diagnostic (ultrasound, ultrasound-guided PAI, FNA, biopsy)Experimental Treatment5 Interventions
Patients undergo standard of care ultrasound of the lymph nodes, then undergo ultrasound-guided PAI over 3-5 minutes. Patients then undergo standard of care ultrasound-guided FNA or biopsy a suspicious lymph node.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fine-Needle Aspiration
2018
Completed Early Phase 1
~40
Lymph Node Biopsy
2014
Completed Phase 2
~50
Ultrasound
2013
Completed Phase 1
~4090
Find a Location
Who is running the clinical trial?
M.D. Anderson Cancer CenterLead Sponsor
3,066 Previous Clinical Trials
1,802,222 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,925 Previous Clinical Trials
41,017,978 Total Patients Enrolled
Priya R BhosalePrincipal InvestigatorM.D. Anderson Cancer Center
3 Previous Clinical Trials
20,071 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am scheduled for a needle biopsy guided by ultrasound.My lymph nodes are not deep (3-5 cm) or small (<1 cm) enough to be excluded.I have melanoma, which may affect test results due to its nature.My cancer diagnosis was confirmed through a biopsy.
Research Study Groups:
This trial has the following groups:- Group 1: Diagnostic (ultrasound, ultrasound-guided PAI, FNA, biopsy)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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