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Stem Cell Therapy

Stem Cell Therapy for Neurological Disorders (NEST Trial)

N/A

Recruiting

Led By Jeffrey Weiss, MD

Research Sponsored by MD Stem Cells

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Have documented functional damage to the central or peripheral nervous system unlikely to improve with present standard of care.

Be over the age of 18 and capable of providing informed consent.

Must not have

Patients must be capable of providing informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0,1,3,6 and 12 months

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether injecting stem cells into the nose can help improve neurologic function in patients with certain conditions.

Who is the study for?

Adults over 18 with stable neurologic conditions like ALS, MS, stroke, or brain injuries not expected to improve with current treatments. They must be at least 6 months post-diagnosis and cleared by a doctor as safe for the procedure. Pregnant women or those who may become pregnant within 3 months post-treatment are excluded.

What is being tested?

The trial is testing whether injecting patients' own bone marrow stem cells into their bloodstream and nasal passages can improve neurological function in various chronic diseases.

What are the potential side effects?

Potential side effects aren't specified but could include typical risks associated with medical procedures such as infection, bleeding, or an adverse reaction to the stem cell transfer.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have lasting nerve damage that current treatments can't fix.

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I am over 18 and can give my consent.

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I have lasting nerve damage that current treatments can't fix.

Select...

I am over 18 and can give my consent.

Select...

I have lasting nerve damage that current treatments can't improve.

Select...

I am over 18 and can give my consent.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am able to understand and agree to the study's procedures and risks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0,1,3,6 and 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0,1,3,6 and 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0,1,3,6 and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Neurologic Function

Secondary study objectives

Neurologic Functioning

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Arm 1- Intravenous and Intranasal BMSCExperimental Treatment1 Intervention

Intervention- Autologous bone marrow aspiration and separation of Bone Marrow Derived Stem Cell (BMSC) fraction then provided intravenously and intranasally (lower 1/3 of nasal passages).

0 / 7Eligibility criteria met