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Exercise Programs for Knee Arthritis

N/A

Recruiting

Led By Prakash Jayabalan, MD, PhD

Research Sponsored by Shirley Ryan AbilityLab

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8

Awards & highlights

No Placebo-Only Group

Summary

This trial will compare 3 exercise protocols to see how they affect knee pain & joint function in people with knee pathology.

Who is the study for?

This trial is for individuals over 50 with knee osteoarthritis, able to walk unaided and have a Kellgren-Lawrence score of 2+ on knee radiographs. Excluded are those under 50, pregnant women, people with certain cardiovascular conditions or extreme body sizes, joint replacements, or neurological disorders affecting leg function.

What is being tested?

The study compares three different 8-week exercise programs for knee osteoarthritis: standard treadmill/community walking, LBPP-supported low-load treadmill walking, and aquatic walking. It aims to assess their impact on serum biomarkers related to joint disease and thigh muscle strength.

What are the potential side effects?

While not explicitly stated in the provided information, potential side effects from these exercises may include muscle soreness, joint pain flare-ups during initial adaptation periods or if improperly performed.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Cartilage oligomeric matrix protein (COMP) serum concentration

Pain subscore on the Knee injury and Osteoarthritis Score (KOOS Survey)

Secondary study objectives

Analysis of cardiovascular parameters

Change in Cardiometabolic (serum adiponectin) concentrations

Change in Inflammatory cytokine (IL-1B) concentration

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Intervention group 2: Aquatic Walking exerciseExperimental Treatment1 Intervention

Participants enrolled in the aquatic exercise program will complete a total of two aquatic walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Each aquatic exercise program will include walking in the pool for 30 minutes at self-selected speeds under the guidance of an aquatic therapy instructor. Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.

Group II: Intervention group 1: Lower-body positive-pressure supported low-load treadmill walking exerciseExperimental Treatment1 Intervention

Participants enrolled in the Lower-body positive-pressure (LBPP) supported low-load treadmill walking exercise will complete a total of two walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Each walking session will include 30-minute walking on a G-Trainer (AlterG Inc., Fremont, CA) under low-load walking conditions. Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.

Group III: Control group: Standard of care land-based walking exerciseActive Control1 Intervention

Participants enrolled in the land-based walking exercise program will complete a total of two community walking or normal treadmill (not LBPP) walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.

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