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Behavioural Intervention

Anti-inflammatory Diet for Osteoarthritis

N/A
Recruiting
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Unilateral radiographic symptomatic KOA
No changes in therapy during the previous 3 months
Must not have
Previous knee surgery
Severe radiographic disease (KL grade 4)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will study the effects of an anti-inflammatory diet on Osteoarthritis symptoms, as well as the role of gut microbes and blood metabolites.

Who is the study for?
This trial is for individuals with one-sided symptomatic knee osteoarthritis who haven't altered their treatment in the last 3 months. They should be interested in dietary changes and able to attend follow-ups. Excluded are those on recent steroids/injections, changing physical activity or diet, smokers, severe knee damage, rheumatoid arthritis, abnormal blood tests, or other conditions affecting nutrition study participation.
What is being tested?
The study examines if an anti-inflammatory diet can improve clinical outcomes for people with Osteoarthritis compared to a standard healthy diet. It also looks at how this diet might affect gut bacteria and body metabolites related to the disease.
What are the potential side effects?
While not typical side effects like with medications, participants may experience changes in digestion or food sensitivities when adjusting to new diets. Specific side effects will depend on individual reactions to dietary changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have knee pain on one side due to arthritis.
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My treatment has been the same for the last 3 months.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have had knee surgery before.
Select...
My X-rays show severe joint damage.
Select...
I have Rheumatoid Arthritis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Knee Osteoarthritis Pain

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm_2Experimental Treatment1 Intervention
Healthy Diet
Group II: Arm_1Active Control1 Intervention
Anti-inflammatory Diet

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,180 Previous Clinical Trials
1,574,975 Total Patients Enrolled
6 Trials studying Osteoarthritis
3,265 Patients Enrolled for Osteoarthritis
~35 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
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