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Alpha-1 Blocker

Prazosin + MRI for Cerebrovascular Disease

Phase 2
Waitlist Available
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Between the ages of 20-40 years
Be between 18 and 65 years old
Must not have
Uncontrolled hypertension
Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up two study visits, up to 240 minutes

Summary

This trial will measure blood flow in the brain while participants are asked to change their posture and breathe in more carbon dioxide using a special imaging technique.

Who is the study for?
This trial is for healthy nonsmokers aged 20-40 with a BMI ≤34.5 kg/m2. It's not for those with major neurological disorders, psychiatric conditions, cardiovascular diseases, contraindications to MRI, severe sleep apnea, uncontrolled diabetes or hypertension, certain medication use, or significant surgical history.
What is being tested?
The study tests how the drug Prazosin affects brain blood flow during simulated postural changes and high carbon dioxide levels using MRI scans. A placebo group is included for comparison.
What are the potential side effects?
Prazosin may cause dizziness or fainting when standing up due to lowered blood pressure (orthostatic hypotension), nasal congestion, headache, weakness and lack of energy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 20 and 40 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My blood pressure is not controlled by medication.
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I do not have major neurological disorders besides dementia.
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I have no severe liver, blood, vascular diseases, or kidney injury needing dialysis.
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I have a history of serious heart conditions.
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I have been diagnosed with Mild Cognitive Impairment or Alzheimer's disease.
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I have had a serious stroke or brain blood vessel disease.
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I am not taking any medications that would interfere with prazosin.
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I have severe sleep apnea that hasn't been treated.
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My diabetes is severe with an HbA1c over 9.5%.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~two study visits, up to 240 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and two study visits, up to 240 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in blood flow
Change in blood velocity

Trial Design

1Treatment groups
Experimental Treatment
Group I: Young AdultsExperimental Treatment3 Interventions
Young Adults between 20-40 years of age.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI
2009
Completed Phase 2
~2810
Placebo
1995
Completed Phase 3
~2670
Prazosin
2010
Completed Phase 4
~1450

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,228 Previous Clinical Trials
3,198,502 Total Patients Enrolled
5 Trials studying Magnetic Resonance Imaging (MRI)
757 Patients Enrolled for Magnetic Resonance Imaging (MRI)
~24 spots leftby Aug 2026
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