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Meditation for Improved Brain Blood Flow During Sleep

N/A
Recruiting
Led By Daniel Claassen, MD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 14-45
Be between 18 and 65 years old
Must not have
Claustrophobia or inability to lie still for prolonged periods of time
Taking benzodiazepines, cholinesterase inhibitors, anti-psychotics, opioids, MAO inhibitors
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 24 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial uses MRI to study how meditation affects the brain's blood flow and metabolism.

Who is the study for?
This trial is for people aged 14-45 who are skilled in meditation. They must be able to undergo MRI scans, meaning no metal implants or issues with confined spaces. Participants should not have recent infections, tattoos, wounds, or consume stimulants/alcohol before the visit. Those with major neurological/psychological conditions or on certain medications like opioids and MAO inhibitors cannot join.
What is being tested?
The study is testing how different states like sleep and meditation affect brain functioning related to fluid movement and metabolism in healthy volunteers using advanced MRI techniques.
What are the potential side effects?
Since this trial involves MRI scanning and meditation without any drugs or invasive procedures, there are minimal side effects expected beyond the discomfort of lying still for long periods during imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 14 and 45 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot stay still for long or am claustrophobic.
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I am currently taking medications like sedatives, painkillers, or drugs for mental health.
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I have been diagnosed with a major neurological or psychological condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 24 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
CSF flow change
Secondary study objectives
EEG changes

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Adept MeditatorsExperimental Treatment1 Intervention
Subjects will undergo scanning during awake, sleep deprived, and meditative states of consciousness.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Meditation
2021
Completed Phase 3
~2940

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
901 Previous Clinical Trials
938,642 Total Patients Enrolled
Daniel Claassen, MDPrincipal InvestigatorVanderbilt University Medical Center
2 Previous Clinical Trials
107 Total Patients Enrolled

Media Library

Meditation Clinical Trial Eligibility Overview. Trial Name: NCT04506892 — N/A
Sleep Clinical Trial 2023: Meditation Highlights & Side Effects. Trial Name: NCT04506892 — N/A
Meditation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04506892 — N/A
Sleep Research Study Groups: Adept Meditators
~12 spots leftby Jul 2026
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