Phantom Limb Pain > DNA Analysis
~52 spots leftby Apr 2026

Study to Identify the Genetic Variations Associated With Phantom Limb Pain

Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine
No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.

Research Team

PF

Paul F. Pasquina, MD, MC

Principal Investigator

Walter Reed National Military Medical Center (WRNMMC)

Eligibility Criteria

Inclusion Criteria

At least 18 years of age.
Written informed consent and written authorization for use or release of health and research study information
Single or multiple upper and/or lower limb amputation
See 7 more

Treatment Details

Interventions

  • Blood Draw (Other)
  • DNA Analysis (Genetic Testing)
  • Protein Analysis (Protein Analysis)
  • RNA Analysis (Gene Expression Profiling)
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Phantom Limb PainExperimental Treatment1 Intervention
Subjects will have lower or upper extremity amputation(s) that have resulted in the presence of phantom limb pain.
Group II: No Phantom Limb PainExperimental Treatment1 Intervention
Subjects in the group will have a lower or upper extremity amputation(s) without the presence of phantom limb sensation.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Henry M. Jackson Foundation for the Advancement of Military Medicine

Lead Sponsor

Trials
103
Recruited
94,300+

Uniformed Services University of the Health Sciences

Collaborator

Trials
130
Recruited
91,100+
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