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HD-tDCS + Language Therapy for Primary Progressive Aphasia
Verified Trial
N/A
Recruiting
Led By Kyrana Tsapkini, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Must be proficient in English
Must have a minimum of high-school education
Timeline
Screening 3 days
Treatment Varies
Follow Up 1 month
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing whether electrical stimulation can help improve language skills in people with neurodegenerative disorders that cause language deficits.
Who is the study for?
This trial is for right-handed individuals aged 50-80 with Primary Progressive Aphasia or dementia, who have completed at least high school and are proficient in English. They must be diagnosed at specialized clinics based on consensus criteria. Healthy controls matched by age and education may also participate.
What is being tested?
The study tests if brain stimulation combined with verbal memory therapy can improve language skills in people with PPA. It compares the effects of stimulating two different brain areas using HD-tDCS during a 'Repeat After Me' treatment versus a sham (placebo-like) procedure.
What are the potential side effects?
Transcranial direct current stimulation (tDCS) may cause mild side effects such as tingling, itching, or discomfort at the electrode site, headache, fatigue, nausea or dizziness. These are usually temporary and resolve soon after the treatment.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 50 and 80 years old.
Select...
I have been diagnosed with Logopenic Variant Primary Progressive Aphasia.
Timeline
Screening ~ 3 days1 visit
Treatment ~ Varies
Follow Up ~ 1 month1 visit
Screening ~ 3 days
Treatment ~ Varies
Follow Up ~1 month
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in percent accuracy on word repetition (no delay) assessed by Temple Assessment of Language and Short-Term Memory in Aphasia (TALSA) Test 3
Change in percent accuracy on word repetition (with 5-sec delay) assessed by TALSA Test 3
Change in percent accuracy on word span assessed by TALSA Test 14
Secondary study objectives
Change in Apraxia Battery of Adults-Second Edition (ABA-2) score
Change in Boston Naming Test (Short-Version) score
Change in Gamma-Aminobutyric Acid (GABA) concentration at stimulated site
+16 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Sham + Language/Cognitive Intervention(s) firstExperimental Treatment2 Interventions
Participants will receive Sham + Language/Cognitive Intervention(s) first and then receive active HD-tDCS + Language/Cognitive Intervention(s) after a three-month washout period.
Group II: Active HD-tDCS + Language/Cognitive Intervention(s) firstExperimental Treatment2 Interventions
Participants will receive active HD-tDCS + Language/Cognitive Intervention(s) first and then receive Sham + Language/Cognitive Intervention(s) after a three-month washout period.
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Who is running the clinical trial?
Johns Hopkins UniversityLead Sponsor
2,327 Previous Clinical Trials
14,874,554 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,789 Previous Clinical Trials
28,188,272 Total Patients Enrolled
Kyrana Tsapkini, PhDPrincipal InvestigatorJohns Hopkins University
6 Previous Clinical Trials
420 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- People who are left-handed.I am between 50 and 80 years old.You use your right hand more often than your left hand.I have been diagnosed with Primary Progressive Aphasia or dementia.You must be diagnosed with primary progressive aphasia (PPA) or its variants at specialized dementia clinics at certain medical centers in the US.I have been diagnosed with Logopenic Variant Primary Progressive Aphasia.The researchers will include 30 healthy people who are similar in age and education level to the participants, usually their spouses, to make sure they have similar language and thinking abilities.I am between 50 and 80 years old.I have a history of neurological or psychiatric conditions.You have hearing loss that has not been treated or fixed.You have very severe memory or language problems, as shown by specific tests.I have a history of neurological diseases like stroke or learning disabilities.You have not corrected your vision loss.
Research Study Groups:
This trial has the following groups:- Group 1: Sham + Language/Cognitive Intervention(s) first
- Group 2: Active HD-tDCS + Language/Cognitive Intervention(s) first
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 30 null
- Follow Ups: You may be asked to continue sharing information regarding the trial for 1 Months after you stop receiving the treatment.
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