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TMS for Post-Traumatic Stress Disorder

N/A
Waitlist Available
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Individuals currently on Benzodiazepine at a dose higher than 3mg or Lorazepam or equivalent
Individuals with previous TMS treatment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 month follow up

Summary

This trial aims to see if adding a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) to regular intensive PTSD treatment can help improve treatment outcomes for veterans with PTSD who are attending

Who is the study for?
This trial is for veterans enrolled in a 2-week intensive outpatient program for PTSD who haven't seen symptom improvement in the first week. Specific eligibility details are not provided, but typically participants must meet certain health and condition-specific criteria.
What is being tested?
The study tests if adding intermittent theta burst stimulation (iTBS) to regular treatment helps improve PTSD symptoms. iTBS will be applied to a brain region called the right dorsolateral prefrontal cortex during the second week of treatment, compared with a sham (placebo-like) procedure.
What are the potential side effects?
While specific side effects are not listed, TMS can generally cause discomfort at the stimulation site, headache, lightheadedness, or seizures in rare cases. The sham procedure should have minimal to no side effects.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am taking more than 3mg of Benzodiazepine or an equivalent drug.
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I have had TMS treatment before.
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My heart condition is stable.
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I do not have major neurological conditions like Parkinson's or MS.
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I am currently pregnant or breastfeeding.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1 month follow up
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1 month follow up for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
PTSD Checklist for DSM-5 (PCL-5)
Secondary study objectives
Patient Health Questionnaire-9 (PHQ-9)

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active TMSActive Control1 Intervention
Group II: ShamPlacebo Group1 Intervention

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Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
439 Previous Clinical Trials
250,216 Total Patients Enrolled
~8 spots leftby Jan 2026
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