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Lung Ultrasound + Doppler for Collapsed Lung

N/A

Recruiting

Led By Martin Girard, MD, FRCPC

Research Sponsored by Centre hospitalier de l'Université de Montréal (CHUM)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Under mechanical ventilation and presenting one or more consolidations on chest radiography or CT scan

Be older than 18 years old

Must not have

Contraindications to superior limbs or torso mobilization

Contraindications to bronchoscopy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during lung ultrasound examination - day 0

Awards & highlights

No Placebo-Only Group

Summary

This trial found that consolidations caused by infection have different effects on the lungs than those caused by other factors.

Who is the study for?

This trial is for mechanically ventilated patients with lung issues like pneumonia or a collapsed lung, visible on chest X-rays or CT scans. It's not for those in other studies, with poor ultrasound imaging conditions (like obesity), recent antibiotic changes, right heart failure, mobility restrictions of upper body, bronchoscopy contraindications, or known high blood pressure in the lungs.

What is being tested?

The study tests how well lung ultrasound and pulsed-wave Doppler can identify different types of lung consolidations by comparing regional acceleration time (RAcT) values between infectious and atelectatic consolidations. Measurements are taken initially and again between days 3 to 5.

What are the potential side effects?

Since this trial involves non-invasive imaging techniques rather than medications, side effects are minimal but may include discomfort from positioning during the ultrasound and potential risks associated with mobilizing critically ill patients.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am on a ventilator and have lung consolidation seen in my chest X-ray or CT scan.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I cannot move my arms or upper body well.

Select...

I cannot undergo bronchoscopy due to health risks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during lung ultrasound examination - day 0

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during lung ultrasound examination - day 0

This trial's timeline: 3 weeks for screening, Varies for treatment, and during lung ultrasound examination - day 0 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

RAcT in lung consolidations

Secondary study objectives

Presence of dynamic air bronchograms in lung consolidations

Presence of sub-pleural consolidations

Presence of visible blood vessels on colour Doppler in lung consolidations

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Lung ultrasound and Doppler, pneumoniaExperimental Treatment1 Intervention

In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed in patients with high clinical suspicion of pneumonia on Day 0. A bronchoalveolar lavage will also be performed on Day 0.

Group II: Lung ultrasound and Doppler, atelectasisExperimental Treatment1 Intervention

Patients without clinically active pulmonary disease but presenting a consolidation of suspected atelectatic nature. Fever, hypothermia, leucocytosis and leucopenia will not be present. Tracheal secretions will remain unchanged. There will be no deterioration of oxygenation. In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0.

0 / 3Eligibility criteria met